DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and tnxba

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_021322558.1	Gene:	tnxba / 100536295	ZFINID:	ZDB-GENE-070103-5	Length:	2285	Species:	Danio rerio

Alignment Length:	869	Identity:	197/869 - (22%)
Similarity:	334/869 - (38%)	Gaps:	238/869 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TSEKPVVHSKQETEAPESSVE--LLRFVDDD------EDSEDISSIERQDGRTMESKKMAD---Q 126
            |:.||.|     ..:|.:|.:  |......|      :.||.:...|:..|:|...|..:|   |
Zfish  1488 TTAKPTV-----KPSPTASTDKVLSHTTGKDNIKIVGQQSESMKLQEQTKGKTTVIKMGSDNQAQ 1547

  Fly   127 VRLLTKQLNA-----------LMLRRREDYEMLEHNL--------RKSLRLTT----------NA 162
            ..|..|..||           ..:::......:.|||        |...::||          ..
Zfish  1548 TDLSDKSHNAKDEPAYQNVTQRSVKKSNGTSKILHNLFKGSMNVTRSKTKITTRTAGDQGEESKT 1612

  Fly   163 NSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNV----AQD 223
            |:|.|:...:|  ....:..:::.:..:|..:...      .|.:..:....:|:|.:    :.:
Zfish  1613 NAVSAEKDEKL--FHGNVTTVQAEKKSDKPEIDAS------VESKAHMKHFSKTSSRLSVIGSVE 1669

  Fly   224 VQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTR 288
            |...:||            ...:...|.|::.:...|..:|::..  .::.:..|..::......
Zfish  1670 VHNITST------------GFIMSWEAHRDKFKNFTVTRREIKAG--NEDSEKIHEAIENVTDAE 1720

  Fly   289 KDGSS-------ASVEEESGSQEANQEQTGLETTADHKRRHCRFQSE--------------QIHQ 332
            :.||:       :|..|.:..::.:|...|  ||..:..:..:.|::              :||:
Zfish  1721 RLGSNRTLTKILSSKSEGNAMKKFSQILAG--TTRSYHFKGLQPQTQYAISLFGSGPGMRSKIHR 1783

  Fly   333 LQLAQRNLRRQVNGLRFHHIDERVRSIE-------VEQHRIANAN--------FNLSSQIAS--L 380
            :.|:..  ......|.|.:|.|...|:.       |.:.::...|        .::.||::.  |
Zfish  1784 ITLSTG--PEPPTDLVFSNITETSFSLSWAKPKSIVAEFKVKYINTVTGESGSMSVDSQLSHVLL 1846

  Fly   381 DKLH---------TSMLELLED---VEGLQTKMDKSIPELRHEISKLEFANAQITSEQSL----- 428
            .||.         :|:|:.||.   :..:.|     :|:     |..|.....||..::|
Zfish  1847 SKLTAGTTYDITVSSVLDKLESEPVIASITT-----VPD-----SPTELKVVNITDTKALLVWKP 1901

  Fly   429 --------IREEGTNAARSLQ-AMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQ-SLVNDEMK 483
                    |...||..:.::. .:.:|.|.::.:...:.:.|..:.::.:.|:||| |.|:....
Zfish  1902 SKAKVDSYILSYGTTKSPNVTITVTLSGSSVEHQLRALHRSSLYMVKMTSQVNRLQSSSVSTSFT 1966

  Fly   484 N----KLTHLNKPHKRPHHQNVQAQMP-----------QDDSPIDSVLAETLVSELE-------- 525
            .    ||..:.......|...:..:.|           |....:..::....|:..|
Zfish  1967 TGSGVKLQVVTPDEVTFHSAVISWKAPRVAFKSYRLTYQLSEEVKELILNPSVTHYELTGLAAFS 2031

  Fly   526 --------NVETQYEAIIN------KLPH----DCSEVHTQTDGLH-----LIAPAGQR-HPLMT 566
                    ..:.||.:.::      :|||    |||||  |.:|:.     .|.|.|:. .|:..
Zfish  2032 NYTVKIDGERDGQYISFVSSDFTTAQLPHPYPTDCSEV--QINGMKESGEAEIYPEGKNGEPVRV 2094

  Fly   567 HC--TADG--WTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQ 627
            :|  ..||  ||..|||.|||.||.|||.||::|||...||||:||:.||.||......|::.::
Zfish  2095 YCDMETDGGAWTVFQRRMDGSTDFFRSWRDYSKGFGLLSGEFWLGNDVLHTLTSLKAMSLRIDLR 2159

  Fly   628 DIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYE 692
            ...|..: |:|..|.|||.|:.|.:.::.|||.|.|::.|.:|..||..|.|.|....|||..|.
Zfish  2160 SGNDTAF-AQYINFNISSEANHYAIDLSGYSGTAGDSMKYHKGRPFSTKDKDPDTLSIHCAKAYM 2223

  Fly   693 GGWWFSHCQHANLNGRY-----NLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFV 752
            ||||:.:|..|||||.|     |.|:.|.|     |....:|      ||..|.:..
Zfish  2224 GGWWYKNCYKANLNGLYASYSDNKGVVWID-----WKGKDAS------LPFTEMKLR-------- 2269

  Fly   753 SVSGSAADAAPSSGATTTTTTATA 776
                      ||:.:.||:||.||
Zfish  2270 ----------PSNFSQTTSTTPTA 2283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	15/110 (14%)
sca	NP_476710.2	FBG	538..736	CDD:214548	88/216 (41%)
tnxba	XP_021322558.1	COG3942	596..>913	CDD:332523
		EGF_2	1380..1406	CDD:285248
		fn3	1792..1870	CDD:306538	16/77 (21%)
		fn3	1880..1952	CDD:306538	11/76 (14%)
		fn3	1976..2037	CDD:306538	5/60 (8%)
		FReD	2061..2270	CDD:238040	88/240 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010