DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and tnxb

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_031747219.1	Gene:	tnxb / 100489649	XenbaseID:	XB-GENE-481849	Length:	2840	Species:	Xenopus tropicalis

Alignment Length:	836	Identity:	179/836 - (21%)
Similarity:	287/836 - (34%)	Gaps:	256/836 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFP---DLQKKKVSRDHLNCPATMAG-SNVLWPIL---------------------LAVVLL--- 42
            |.|   |||..::.:|.:|....:.| |:..|.::                     |...||
Frog  2164 TIPRLVDLQANEIGKDSVNLSWRVEGESSFDWIVVQYGGPDGVVREQQVPGGDTSTLVTGLLPSR 2228

  Fly    43 --------------------QISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHS-KQETE 86
                                :|...|:.........|:|:        .|:...|  || ....:
Frog  2229 RYKFSLYGIKGQKHSKPLSTEIETGFLEAVGQPSSFLNDL--------FVSPHGP--HSILVSWQ 2283

  Fly    87 APESSVE--LLRF-VDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLRRREDYEML 148
            |||.|.:  ::|: ::..|..:..:|: ....||:          ||..      |:....|::.
Frog  2284 APEGSFDSFVIRYGIEGHEKPQKEASV-NGTARTL----------LLAN------LQPDTPYKVK 2331

  Fly   149 EHNLRK-----SLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRK 208
            .|.:|:     ||..|....|:|.:....|
Frog  2332 LHGVRRGKEQGSLETTGRTGSLDLEPPQNL----------------------------------- 2361

  Fly   209 QLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQE 273
            :..|::.|:..|:.|.....:|     |.:..||     ||...|.:....|
Frog  2362 RFNDVEETSLTVSWDPPNPETT-----TFKVSYQ-----LAKGGEPESVNVV------------- 2403

  Fly   274 QDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETT---ADHKRRHCRFQSEQIHQLQL 335
             ....:|.:|...||.:.:..||.   |.:| :|..||..||   ..|        |...|.:..
Frog  2404 -GDSKSLQRLNVGTRYEVTVVSVR---GFEE-SQPLTGYITTGGGGPH--------SLHAHDVTE 2455

  Fly   336 AQRNLR---------RQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQ-IASLDKLHTSMLEL 390
            ....||         |.|...|..::......:..:|..:..:..|..:: .||:..||.|.|..
Frog  2456 ESALLRWEPEPGFVDRYVVTYRAENVLSVTHEVPGDQTELPISGLNPHTEYYASVQSLHGSKLSS 2520

  Fly   391 LEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEERE 455
            ......: |..|          :..|...:|||::.:|:      ..:..|.:.....::.:..:
Frog  2521 PTSTSFI-TSAD----------TPRELLASQITAQSALL------TWKPPQVVPDGYRLVYQTHD 2568

  Fly   456 GMRK---LSANVDQLRTNVDRLQSLVNDEMKNKLTHL--NKPHKRPHH--QNVQAQMPQDDSPID 513
            |..|   |.||:...                 .|:||  :.|:|...|  :...:..|
Frog  2569 GEIKELILLANLSSF-----------------TLSHLTPSTPYKVQLHALRGASSSAP------- 2609

  Fly   514 SVLAETLVSELENVETQYEA--IINKLPHDCSEVHTQTD---GLHLIAPAGQR-HPLMTHCTAD- 571
                         :.|.:..  |....|.||.|.|...|   |:..|...|.: .||:.:|..:
Frog  2610 -------------ISTSFTTGRIRYPFPRDCWEKHMNGDLQSGVFTIYLGGSKDDPLLVYCDMET 2661

  Fly   572 ---GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNV 633
               ||...|||.||..||.|:|..|.:|||....|||:||..||.|:......|:|.::...:..
Frog  2662 DGGGWIVFQRRIDGRTDFWRNWRQYKEGFGNLTSEFWLGNIALHRLSSLAPYELRVDLRAGAEAA 2726

  Fly   634 WVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFS 698
            : |.|:.|.:......:||.|..|.|||.|:|:|...|.||..|.|.:.....|:.:|.|.||:.
Frog  2727 Y-AVYEDFRVEGEDKHFRLRIGAYRGNAGDSLSYHNNMIFSTRDRDAEKRILPCSISYRGAWWYK 2790

  Fly   699 HCQHANLNGRY-----NLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASG 749
            :|.:|||||.|     :.|:.|     :.|...:.|      :|..|.:.....:|
Frog  2791 NCHYANLNGMYGNNKDHQGVNW-----HTWKGFEFS------IPFTEMKMRPQRTG 2835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	18/99 (18%)
sca	NP_476710.2	FBG	538..736	CDD:214548	71/210 (34%)
tnxb	XP_031747219.1	EGF_Tenascin	179..206	CDD:376143
		exchanger_TraA	<400..779	CDD:411343
		EGF_Tenascin	799..826	CDD:376143
		fn3	834..913	CDD:394996
		FN3	923..998	CDD:214495
		fn3	1790..1852	CDD:394996
		fn3	1881..1960	CDD:394996
		fn3	1972..2051	CDD:394996
		fn3	2064..2141	CDD:394996
		fn3	2170..2245	CDD:394996	11/74 (15%)
		fn3	2267..2338	CDD:394996	20/97 (21%)
		FN3	2356..2433	CDD:238020	21/139 (15%)
		fn3	2445..2522	CDD:394996	16/84 (19%)
		fn3	2531..2609	CDD:394996	18/110 (16%)
		FReD	2622..2831	CDD:238040	73/220 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910