DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and tnr

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	NP_001107287.1	Gene:	tnr / 100135076	XenbaseID:	XB-GENE-948286	Length:	1350	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	95/365 - (26%)
Similarity:	156/365 - (42%)	Gaps:	75/365 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 LLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEER 454
            :|.|.|.::.::...:|...:.:              :|....|...:||   :.||.:.:
Frog   992 ILVDGESIEFQLQNLLPRTNYSV--------------TLSANFGHQTSRS---VGVSFTTI---- 1035

  Fly   455 EGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVL-AE 518
                 |...::...|.|.|..:|::.:          |...|....:......::|..:.:: ||
Frog  1036 -----LDPPMNLTATEVARTSALISWQ----------PPISPIENYILTYKSANESRKELIVDAE 1085

  Fly   519 TLVSELENV--ETQYEAIINKL----------------------PHDCSEVHTQTD---GLHLIA 556
            .....||.:  .|:|...|..:                      |.||::.....|   |::.|.
Frog  1086 DTWIRLEGLLESTEYTVSILSVQNGERSSVTHTVFTTGGRVFSYPQDCAQHMLNGDNQSGVYYIY 1150

  Fly   557 PAG---QRHPLMTHCTAD--GWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTL 616
            ..|   |..|:......|  ||...|||.:|..||.|.||||..|||....|||:|.:.||.:|.
Frog  1151 INGDMSQSVPVYCDMATDAGGWIVFQRRQNGLTDFFRKWADYRVGFGNLEDEFWLGLDTLHQVTS 1215

  Fly   617 DNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRD 681
            .....|::.|:|..:.|: |.|.:|.|......|:|.|.:::|.:.|:|.|.||..||..|.|.|
Frog  1216 QGRYELRIDMRDGQEAVY-AYYNKFNIGDARSLYKLRIGDFNGTSGDSLTYHQGRPFSTKDRDND 1279

  Fly   682 ISQTHCAANYEGGWWFSHCQHANLNGRY-----NLGLTWF 716
            ::.|:||::|:|.||:.:|...||||:|     :.|:.|:
Frog  1280 VAVTNCASSYKGAWWYKNCHRTNLNGKYGESRHSQGINWY 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343
sca	NP_476710.2	FBG	538..736	CDD:214548	70/214 (33%)
tnr	NP_001107287.1	EGF_alliinase	153..196	CDD:282688
		EGF_2	198..223	CDD:285248
		EGF_2	260..285	CDD:285248
		EGF_2	292..316	CDD:285248
		FN3	321..410	CDD:238020
		fn3	413..493	CDD:278470
		fn3	502..582	CDD:278470
		FN3	592..676	CDD:238020
		fn3	684..763	CDD:278470
		fn3	773..840	CDD:278470
		fn3	862..939	CDD:278470
		fn3	949..1018	CDD:278470	5/39 (13%)
		FN3	1037..1122	CDD:238020	14/94 (15%)
		FReD	1129..1337	CDD:238040	70/192 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910