DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sca and fgl2b

DIOPT Version :9

Sequence 1:	NP_476710.2	Gene:	sca / 36411	FlyBaseID:	FBgn0003326	Length:	799	Species:	Drosophila melanogaster
Sequence 2:	XP_001341185.5	Gene:	fgl2b / 100001116	ZFINID:	ZDB-GENE-120709-53	Length:	1447	Species:	Danio rerio

Alignment Length:	766	Identity:	161/766 - (21%)
Similarity:	302/766 - (39%)	Gaps:	168/766 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VVLSDV-------NNMLRDAKVVTSEKP-----VVHSKQETEAPESSVELLRFVDDDEDSEDISS 109
            |:.|:|       ||:........|:.|     :...::....|..:.|::...:::..|:|.::
Zfish   756 VITSNVLDNQQSTNNITEPKSQPESQNPGDIRDLDKVQEAMNRPGDNSEIVLISNNENRSQDPNT 820

  Fly   110 IER---------QDGRTM---------ESKKMADQVRLLTKQLNALMLRRREDYEMLEHNLRK-- 154
            ::|         ::|:..         ::....|::|         ..|:|.....|:..|.|
Zfish   821 MQRGTSNSPAGEKEGKIFSLGGASISGQNPSEEDKIR---------SGRKRPTTSTLKKELPKEP 876

  Fly   155 --SLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTA 217
              |..:|:|.:..|.:....:..: ..:......:|.|..:                  |..|:.
Zfish   877 GASQFITSNVSFTDMEHGDSMKNI-HTVTNTHVEKSNNPSQ------------------DTPRSF 922

  Fly   218 SNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQR-------ERQQQTEVYVQELREEMLQQEQD 275
            .|.......||:...:| .|:::..:.|....:|.       ::.||.:.:|::..|
Zfish   923 ENTGPAPNVRSTVLHNL-WIKNNNTESKSPPISQNAANVQDLDQVQQGKTHVRDNSE-------- 978

  Fly   276 FQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLET------TADHKRRHCRFQSEQIHQLQ 334
                 |.|...|.......::::..||   |...:|.|.      |||...|    ..:..:...
Zfish   979 -----VVLILNTENSEEDPNIQQSGGS---NVPTSGTERKTFSLGTADKLER----GKKGTNTPT 1031

  Fly   335 LAQRNLRRQVNGLRFHHIDERVRSIEVEQHR--------IANANFNLSSQIASLDKLHTSMLELL 391
            |.::.|.:.....:|  |:..|...:: |||        :.||:..:...::....:....:...
Zfish  1032 LKKKELFKDPGTTQF--INSTVSFTDM-QHRDSTKNTGSVTNAHVEMPKNVSRDTPISFESIGAT 1093

  Fly   392 EDVEGLQTKMDK--SIPE-LRHEISKLEFANAQITSEQSL--IREEGTNAARSLQAMAVSVSVLQ 451
            :::|.::...|:  .||| :....:.::.||.....:.::  :.|..||......:...|:|. :
Zfish  1094 KELEHIKLNKDRVDEIPEDVLSNPNTVDTANGYSGEKYAIPVVLETLTNTEEIKGSKVFSLSP-E 1157

  Fly   452 EEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVL 516
            :..||. |..|..|:: |..::.::.::..........:.||.:|  ...|.:.|
Zfish  1158 DTAEGF-KSHAVSDEV-TEREKAENKIHSTCLGNCNTTSTPHSQP--STSQTRTP---------- 1208

  Fly   517 AETLVSELENVETQYEAIINKLPHDCSEVHTQT--DGLHLIAPAGQRHPLMTHC----TADGWTT 575
               |..|.|....|          ||::..|::  :|::.:.|..:.......|    :..|||.
Zfish  1209 ---LAPEREKRPAQ----------DCADYITKSRRNGVYRVTPRPKNTTFPVFCDMASSGGGWTL 1260

  Fly   576 VQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKR 640
            :|.|||||..|||:|.:|..|||...||||:||:::|.||......|:::::|.......|:|..
Zfish  1261 IQHRFDGSTSFNRTWDEYKNGFGKLIGEFWLGNDKIHLLTKAKNMSLRIEIEDFEGIREYAQYDH 1325

  Fly   641 FYISSRADGYRLHIAEYSGNASDALNYQQGMQ-----FSAIDDDRD-ISQTHCAANYEGGWWFSH 699
            |||::.:..|||.|..|||.|.:|:.:.:...     |:..|.|.| ....:|.|.|..||||..
Zfish  1326 FYIANESQQYRLSIDGYSGTAGNAMQFSKKYNHDQKFFTTPDRDNDQYPSGNCGAYYSSGWWFDA 1390

  Fly   700 CQHANLNGRY--------NLGL---TWFDAA-----RNEWIAVKSSRMLVK 734
            |..|||||:|        ..|:   ||.:..     .||..:.::.||:::
Zfish  1391 CMSANLNGKYYQSKYKGVRNGIFWGTWHNITMEYYPTNERQSFRTVRMMIR 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sca	NP_476710.2	PRK13923	<200..300	CDD:276343	16/106 (15%)
sca	NP_476710.2	FBG	538..736	CDD:214548	73/225 (32%)
fgl2b	XP_001341185.5	FReD	1219..1442	CDD:238040	74/233 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810