DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12374 and ECM14

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_012000.1	Gene:	ECM14 / 856533	SGDID:	S000001174	Length:	430	Species:	Saccharomyces cerevisiae

Alignment Length:	457	Identity:	121/457 - (26%)
Similarity:	195/457 - (42%)	Gaps:	106/457 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIHEHISVHFLNELGAVGNKYNVIVGP 74
            |..::|...|...:...|..:.:|:.|             .::.|....:.:..:.:.|:|
Yeast    12 LFVLLAVTGAVQGLQEDYSEYAVYRFT-------------SDNYSTLVRDVIAPLTDDYDV---- 59

  Fly    75 LFHRALEKTLKFLEIVY-----------EVIVDDLQKLI------------DESSVGDDSQMEWE 116
                 ..::..|::|..           :||:|::.:||            :::...:|....:.
Yeast    60 -----WTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMAREQAVFENDYDFFFN 119

  Fly   117 TYHTLDTIYDWID-QECAAHDFLECKVIGQSYEGRDIKSIRLS--KRSGN---KAIFLEGNIHAM 175
            .|..|||||.|:| .|.:....:..:.:|:::|||::|::.:|  |...|   |.|.:.|.|||.
Yeast   120 EYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITGGIHAR 184

  Fly   176 EWISSATVTFLLNQLIN---SEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGY 237
            ||||.:||.:.|.||:|   |...|.:.| ::.|::|:|:.||||:.||...:|||||||:
Yeast   185 EWISVSTVCWALYQLLNRYGSSKKETKYL-DDLDFLVIPVFNPDGYAYTWSHDRLWRKNRQ---- 244

  Fly   238 RNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGY-IRSY 301
            |.....|.|||::.:|.:.|..|.   ...|...:.||.|....|..:...:::..:..| |..|
Yeast   245 RTHVPQCLGIDIDHSFGFQWEKAH---THACSEEYSGETPFEAWEASAWYKYINETKGDYKIYGY 306

  Fly   302 MAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKD 366
            :..|:|.|.:|.||.:|....|.:.|.:..::...|.|.....|.          ||.|..|.||
Yeast   307 IDMHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGR----------NYDVISACKD 361

  Fly   367 ------------------------WAYGVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAG 407
                                    ||:.:|         |||.|..||.||...|..||.|..|.
Yeast   362 RGSDIFPGLGAGSALDFMYHHRAHWAFQLK---------LRDTGNHGFLLPPENIKPVGKETYAA 417

  Fly   408 LK 409
            ||
Yeast   418 LK 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	11/92 (12%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	104/326 (32%)
ECM14	NP_012000.1	M14_CP_A-B_like	121..425	CDD:349433	104/326 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
TreeFam	0	0.000	Not matched by this tool.
	5	4.910