DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and AGBL2

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	287	Identity:	59/287 - (20%)
Similarity:	104/287 - (36%)	Gaps:	99/287 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AARYDHFRIYQLTIETNL-----------QMEELKK--IHEHISVHFL--NELGAVGNKYNVIVG 73
            |.|.|.:. |:||:.|:|           :::..:|  .:....|:.|  ..|..||.|
Human   280 AVRVDTYE-YELTLRTDLYTNKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMK------ 337

  Fly    74 PLFHRALEKTLKFL-------EIVYEVIVDDLQKLIDESSVGDDSQ----MEW--ETYHTLDTI- 124
            ||.:..|:...:.:       ||.|.           :::..|..|    :.|  :..:..||.
Human   338 PLLYSQLDANTRNIGWRREGNEIKYY-----------KNNTDDGQQPFYCLTWTIQFPYDQDTCF 391

  Fly   125 ------YDWIDQEC---------AAHDFLECKVIGQSYEGRDIKSIRLSKRS-------GNKAIF 167
                  |.:.|.:|         ....|.:.:.:.:|..|..:..:.::..|       ..||:.
Human   392 FAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVV 456

  Fly   168 LEGNIHAME----WISSATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLW 228
            |...:|..|    |:....:.|:|     |..|:.|.|.:.:.:.|:||:||||.:.
Human   457 LSARVHPGESNGSWVMKGFLDFIL-----SNSPDAQLLRDIFVFKVLPMLNPDGVIV-------- 508

  Fly   229 RKNRRPNGYRNESGDC--YGIDMNRNF 253
                  ..||     |  .|.|:||::
Human   509 ------GNYR-----CSLAGRDLNRHY 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	17/91 (19%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	35/165 (21%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	30/142 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900