DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and Agbl3

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001276585.1	Gene:	Agbl3 / 76223	MGIID:	1923473	Length:	1006	Species:	Mus musculus

Alignment Length:	279	Identity:	63/279 - (22%)
Similarity:	106/279 - (37%)	Gaps:	94/279 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DHFRIYQLTIE----------------TNLQMEELKKIHEHISVHFLNELGAVGNKYNVIVGPLF 76
            ||  .|:||:.                ||.|.|   .::....|:|...    .:.||..:.|||
Mouse   193 DH--EYELTVRPDLFTNKHTQWYYFQVTNTQAE---IVYRFTIVNFTKP----ASLYNRGMKPLF 248

  Fly    77 HRALEKTLKFLEIVYEVIVDDLQKLIDESSVGDDSQ----MEWETY---HTLDTIY--------- 125
            :.  ||..|...|.::.|.|.::..  ::::|.|.:    :.| |:   |:.||.|
Mouse   249 YS--EKEAKTHNIGWQRIGDQIKYY--KNNLGQDGRHFFSLTW-TFQFPHSQDTCYFAHCYPYTY 308

  Fly   126 -------DWIDQECAAHDFLECKVIGQSYEGRDIKSIRL--------SKRSGNKAIFLEGNIHAM 175
                   ..|:.:.....|.:.:|:..:.....:..:.:        |||   ||:.|...:|..
Mouse   309 SNLQEYLSGINSDPVRSKFCKIRVLCHTLARNMVYVLTITTPLKTSDSKR---KAVILTARVHPG 370

  Fly   176 E----WISSATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNG 236
            |    ||....:.::|.   :|.|..:  |.:.:.:.||||:||||.:.              ..
Mouse   371 ETNSSWIMKGFLDYILG---DSSDARL--LRDTFIFKVVPMLNPDGVIV--------------GN 416

  Fly   237 YRNESGDC--YGIDMNRNF 253
            ||     |  .|.|:|||:
Mouse   417 YR-----CSLAGRDLNRNY 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	19/85 (22%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	37/169 (22%)
Agbl3	NP_001276585.1	M14_AGBL2-3_like	315..576	CDD:133117	33/143 (23%)
Agbl3	NP_001276585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900