DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and Cpa3

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_062173.1	Gene:	Cpa3 / 54242	RGDID:	2390	Length:	417	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	116/401 - (28%)
Similarity:	212/401 - (52%)	Gaps:	31/401 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RYDHFRIYQLTIETNLQMEELKKIHEHISVHF-----LNELGAVGNKYNVIVGPLFHRALEKTLK 85
            ::|..:::::.::...|...||.:.:.|.:.|     :::: ||....:..|.....:.::.||:
  Rat    20 QFDREKVFRVKLQDEKQASILKNLTQTIELDFWYPDAIHDI-AVNMTVDFRVTEKESQTIQSTLE 83

  Fly    86 FLEIVYEVIVDDLQKLID------ESSVGDDSQMEWETYHTLDTIYDWIDQECAAHDFLECKV-I 143
            ..::.||::::|||:.||      |...|..|   :..|:..:.|..|.::....|..:..:: |
  Rat    84 QHKMDYEILINDLQEEIDKQFDVKEEIAGRHS---YAKYNDWNKIVSWTEKMVEKHPEMVSRIKI 145

  Fly   144 GQSYEGRDIKSIRLSKRSG-NKAIFLEGNIHAMEWISSATVTFLLNQLINS--EDPEMQRLSEEY 205
            |.:.|...:..:::.::.| .||||::..|||.||:|.|...:.:.|...|  ::..|.:|.:..
  Rat   146 GSTVEDNPLYVLKIGRKDGERKAIFMDCGIHAREWVSPAFCQWFVYQAAKSYGKNKIMTKLLDRM 210

  Fly   206 DWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDH 270
            ::.|:|:.|.||::::...:|:|||||.    :|.:..|.|.|:|||||..|..:. |.|.||..
  Rat   211 NFYVLPVFNVDGYIWSWTKDRMWRKNRS----KNPNSTCIGTDLNRNFDVSWDSSP-NTDNPCLS 270

  Fly   271 WFGGEEPNTEVEIISLQNFVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAA 335
            .:.|..|.:|.|..::.||:.|..:. |::|:.:|:|.|.:|.|||:: .:.|||::.:.::|..
  Rat   271 VYRGPAPESEKETKAVTNFIRSHLNS-IKAYITFHSYSQMLLFPYGYT-IKLPPNHQDLLKVARI 333

  Fly   336 FSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAY--GVKKIPFTCTVELRDKGTFGFFLPSNQIT 398
            .:|..:..|.:.:.||......|..||::.||||  |:|   .|...||||||..||.||.::|.
  Rat   334 ATDVLSSRYETRYIYGPIASTIYKTSGSSLDWAYDLGIK---HTFAFELRDKGKSGFLLPESRIK 395

  Fly   399 EVGLEVTAGLK 409
            ....|....:|
  Rat   396 PTCKETMLSVK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	17/80 (21%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	95/298 (32%)
Cpa3	NP_062173.1	Propep_M14	28..102	CDD:280416	16/74 (22%)
Cpa3	NP_062173.1	Peptidase_M14_like	114..413	CDD:299699	96/306 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3014
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800