Protein Alignment CG12374 and CPA4

DIOPT Version :10

• Sequence 1: NP_610819.1
• Gene: CG12374 / 36410
• FlyBaseID: FBgn0033774
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_057436.2
• Gene: CPA4 / 51200
• HGNCID: 15740
• Length: 421
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 124/394 - (31%)
• Similarity: 205/394 - (52%)
• Gaps: 40/394 - (10%)

  Fly    44 EELKKIHE-----HISVHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLID 103
            :|:.|:.:     ::.::|.....:.....:|:|..:..:|.:..|:...:.|.|.::|||.|:|
Human    35 DEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLD 99

  Fly   104 ESSVGDDSQME-------------WETYHTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIKS 154
                .:|.:|:             :..||:|:.||..:|...|....|..:| ||.|:|.|.:..
Human   100 ----NEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYV 160

  Fly   155 IRLSKRSG--NKAIFLEGNIHAMEWISSATVTFLLNQLIN--SEDPEMQRLSEEYDWIVVPMVNP 215
            ::.|...|  ..|::|...||:.||||.||..:...::::  ..||.:..:.|:.|..::|:.||
Human   161 LKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANP 225

  Fly   216 DGFVYTHEVERLWRKNRRPNGYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTE 280
            ||:|||....|||||.|.    ||....|.|.|.|||::..:.|.|.: |.||...:.|...|:|
Human   226 DGYVYTQTQNRLWRKTRS----RNPGSSCIGADPNRNWNASFAGKGAS-DNPCSEVYHGPHANSE 285

  Fly   281 VEIISLQNFVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYG 345
            ||:.|:.:|:.  :.|..:.::..|:|.|.::.|||:| .:..|:.|::.::|...:.|.|.|.|
Human   286 VEVKSVVDFIQ--KHGNFKGFIDLHSYSQLLMYPYGYS-VKKAPDAEELDKVARLAAKALASVSG 347

  Fly   346 STFTYGASGLLNYVVSGAAKDWAY--GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGL 408
            :.:..|.:....|..||::.||||  |:|   |..|.||||.||:||.||:|||.....|...||
Human   348 TEYQVGPTCTTVYPASGSSIDWAYDNGIK---FAFTFELRDTGTYGFLLPANQIIPTAEETWLGL 409

  Fly   409 KALV 412
            |.::
Human   410 KTIM 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	33..104	CDD:460505	13/64 (20%)
		M14_CP_A-B_like	118..413	CDD:349433	108/302 (36%)
CPA4	NP_057436.2	Propep_M14	27..101	CDD:460505	14/69 (20%)
		M14_CPA	118..419	CDD:349442	108/307 (35%)