DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and CG14820

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	166/424 - (39%)
Similarity:	249/424 - (58%)	Gaps:	19/424 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLPILLITLVAMVA-AKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIH---EHISVHFLNEL 61
            |.|.|||:  |.:.. |:|..   ..|||::::|.:.|:   .:|:.|.:|   ..:.:....|.
  Fly     1 MLLKILLV--VGLFGLARSVE---QVRYDNYKVYNVRID---DLEQFKLLHTQERSLKLSSWREA 57

  Fly    62 GAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDESSVGDD-SQMEWETYHTLDTIY 125
            ..:|...::::.|.:.:..|..|......|.:.:|::|..||....... :.|||..:|||:.||
  Fly    58 RHLGESSDIMLPPEYQKTFESLLTKHNFTYNLKIDNVQTHIDAQRPKQRITSMEWTQFHTLEEIY 122

  Fly   126 DWIDQ-ECAAHDFLECKVIGQSYEGRDIKSIRLSKRSGNKAIFLEGNIHAMEWISSATVTFLLNQ 189
            .|:|. |....|.:....||.|||||.|:.:::|.:.||.|:|:|.||||.|||:|||:|:.:::
  Fly   123 AWLDVIEDRYPDIVTPFTIGNSYEGRPIRGVKISYKEGNPAVFIESNIHAREWITSATITYFIDE 187

  Fly   190 LINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNESGDCYGIDMNRNFD 254
            |:...:|.::.:::..||.::|::|.|||.|:|||||||||:|.|:   :.:|:|.|.|:|||||
  Fly   188 LLVPRNPAVRDIAQNVDWYIIPVLNTDGFAYSHEVERLWRKSRLPS---DPTGECIGTDLNRNFD 249

  Fly   255 YHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFV-SSFEDGYIRSYMAYHAYGQYVLLPYGHS 318
            |.|...|...| ||...:.|..|.::.||..|..:: :|..:|.|:.|::.|:||||||.|:||:
  Fly   250 YLWMLTGAESD-PCSQLYAGPSPESDPEISQLTAYINNSIPEGTIKIYISLHSYGQYVLSPWGHT 313

  Fly   319 NTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAYGVKKIPFTCTVELR 383
            ..|||.:|.||..:|..||||....||:.||||:|....|.|||:.|:|||.||.|....|:|||
  Fly   314 ALEFPEHYPQMMHVAKGFSDALYRRYGTVFTYGSSATTLYEVSGSGKEWAYAVKNIKIHYTIELR 378

  Fly   384 DKGTFGFFLPSNQITEVGLEVTAGLKALVNKAAE 417
            |||..||.||...|..|..|||.|...::..|.|
  Fly   379 DKGELGFVLPPEDIIPVAREVTEGFVGMIAAARE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	13/72 (18%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	135/298 (45%)
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	13/71 (18%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	135/298 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468815
Domainoid	1	1.000	225	1.000	Domainoid score	I2535
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3154
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	10	9.900