DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and CG17633

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	152/443 - (34%)
Similarity:	225/443 - (50%)	Gaps:	45/443 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIH-EHISVHFLNELGAVGNKYN 69
            ||..|:|:||:.|.... ..|||::|:|::..|...|:|.||.:. ...|:.||:.:..||....
  Fly     7 LLFALLAIVASASVSAE-RVRYDNYRMYKVNSENAKQLEVLKDLEGSSDSIMFLDGVHLVGADIQ 70

  Fly    70 VIVGPLFHRALEKTLKFLEIV------YEVIVDDLQKLIDESSVGDD---------SQMEWETYH 119
            :||.|      .|...||||:      ||:...|:||.:||.   |:         :...|..|:
  Fly    71 IIVAP------HKVPDFLEILGKSEIKYELQSRDVQKSLDEI---DEKVAIKGRATTAYNWAQYY 126

  Fly   120 TLDTIYDWIDQECAAHDFLECKVI-GQSYEGRDIKSIRLSKRS---GNKA---IFLEGNIHAMEW 177
            .||..|.|:......:..:...:. |::|:||.|..::::|..   ..||   ||||..|||.||
  Fly   127 ELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKPGIFLEAGIHAREW 191

  Fly   178 ISSATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNESG 242
            |:.|..||::|||:.||...::.|:|.|.|.|:|..||||:||||...|||||.|.|      .|
  Fly   192 IAPAAATFIINQLLTSEVENIKELAENYTWYVLPHANPDGYVYTHTTNRLWRKTRTP------YG 250

  Fly   243 DCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRSYMAYHAY 307
            .|:|.|.|||:.:||...|.: ...|...:.|....:|:|.:||..|:...: |.::.|::.|||
  Fly   251 SCFGADPNRNWGFHWNEVGAS-SSACSDTYAGPSAFSEIETLSLSKFIEGLK-GKVQLYLSLHAY 313

  Fly   308 GQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAYGVK 372
            .||:|.||||: ::.|.|....:::..|...|....||:|:|.|......|..:||:.|||||.:
  Fly   314 SQYLLYPYGHT-SDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAAGASVDWAYGTQ 377

  Fly   373 KIPFTCTVELRDKGT---FGFFLPSNQITEVGLEVTAGLKALVNKAAEEGIFD 422
            .:......|||...|   .||.||:.||.....|:...:.|:..:....|.||
  Fly   378 DVRMAFCYELRPSSTSYLTGFKLPAEQIVPASEELLDSIVAMATEVKSLGYFD 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	23/76 (30%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	110/306 (36%)
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	134/385 (35%)
		Propep_M14	34..105	CDD:280416	23/76 (30%)
		M14_CP_A-B_like	125..423	CDD:199844	110/306 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467039
Domainoid	1	1.000	225	1.000	Domainoid score	I2535
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3154
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	11	10.910