DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and CG18585

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001260213.1	Gene:	CG18585 / 34041	FlyBaseID:	FBgn0031929	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	171/445 - (38%)
Similarity:	260/445 - (58%)	Gaps:	51/445 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLPILLITLVAMVAA---KSAPGRMAARYDHFRIYQLTIETNLQMEELKKIHEHISVHFLNELG 62
            |:|..||.||||:.:|   |.:|   ..|||:||:|:|||:..:|:..::||            |
  Fly     1 MRLLWLLATLVALTSAGILKDSP---KERYDNFRVYKLTIQNKIQLAAIEKI------------G 50

  Fly    63 AVGNKYN-------------VIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDESSV---GDDS 111
            .:..|||             ::|.|......::.|||..|..|::::::|:.|||..|   .|.:
  Fly    51 ELTKKYNIWKEYDERSRQIDIMVSPGELNHFQELLKFNNISSELMIENVQERIDEEQVTPTADSA 115

  Fly   112 QMEWETYHTLDTIYDWIDQECAAH-DFLECKVIGQSYEGRDIKSIRLSKRSGNKAIFLEGNIHAM 175
            ...|..|:.|:.|..|:|:...|: ...|..::|:|||||.|:.|::|.::||..||:|.||||.
  Fly   116 TFGWTKYYELEEIEAWLDEILNAYPSVTEEFIVGKSYEGRTIRGIKISHKAGNPGIFIESNIHAR 180

  Fly   176 EWISSATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNE 240
            |||:||:.|:.:|||:.|||.:::.|::.|||.::|:.|.|||.|:|:.:|:|||.|:|:.
  Fly   181 EWITSASATWFINQLLTSEDADVRSLADNYDWHIIPVFNVDGFEYSHKKDRMWRKTRQPHA---- 241

  Fly   241 SGDCYGIDMNRNFDYHW---GGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRSYM 302
            :..|.|.|.|||||.:|   .||.   |.||...|.|:.|.:|.|..:|..:::..:| .|..|:
  Fly   242 TNACIGADANRNFDSYWLQNNGAS---DNPCSETFAGDNPESEPEAKALVEYLTKIQD-QISVYI 302

  Fly   303 AYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDA-AADVYGSTFTYGASGLLNYVVSGAAKD 366
            ::|:||||:|.||||:|.|||.||..:..|..||:|| .|..||:.:.||::..:.||.:|.:.|
  Fly   303 SFHSYGQYLLSPYGHTNEEFPENYNDILTIGKAFADAIEALPYGTVYQYGSTADVLYVATGTSVD 367

  Fly   367 WAYGV--KKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLKALVNKAAEEG 419
            |.:..  |||.:  |:|.||||.:||.||..||.....|:..|:.||:.|..|.|
  Fly   368 WVFNELGKKIGY--TIEYRDKGRYGFILPPVQIIPNCEELMVGMLALIEKTKELG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	19/82 (23%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	127/303 (42%)
CG18585	NP_001260213.1	Propep_M14	34..105	CDD:280416	19/82 (23%)
CG18585	NP_001260213.1	M14_CP_A-B_like	122..415	CDD:199844	127/302 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468816
Domainoid	1	1.000	158	1.000	Domainoid score	I1007
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3154
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46992
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	10	9.900