DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and Cpb1

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_036665.2	Gene:	Cpb1 / 24271	RGDID:	2391	Length:	415	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	134/445 - (30%)
Similarity:	221/445 - (49%)	Gaps:	66/445 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLITLVAMVAAKSAPGRMAARYDHF---RIYQLTI----ETNLQMEELKKIHEHISVHFLNELG 62
            :||:.||::..|.       |..:||   |:|::::    ..|| ::||....|   :.|.....
  Rat     2 LLLLALVSVALAH-------ASEEHFDGNRVYRVSVHGEDHVNL-IQELANTKE---IDFWKPDS 55

  Fly    63 AVGNKYNVIVGPL----FH------RALEKTLKFLEIVYEVIVDDLQKLIDESSVGDDSQMEWET 117
            |..      |.||    ||      ..:|..|:..|:.|||::.:::..:       :||.:..|
  Rat    56 ATQ------VKPLTTVDFHVKAEDVADVENFLEENEVHYEVLISNVRNAL-------ESQFDSHT 107

  Fly   118 ---------YHTLDTIYDWIDQECAAH-DFLECKVIGQSYEGRDIKSIRLSKRSGNK-AIFLEGN 171
                     |:..:||..||.|....: |.:...|||.::|||::..:::.|...|| |||::..
  Rat   108 RASGHSYTKYNKWETIEAWIQQVATDNPDLVTQSVIGTTFEGRNMYVLKIGKTRPNKPAIFIDCG 172

  Fly   172 IHAMEWISSATVTFLLNQLINSEDPE--MQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRP 234
            .||.||||.|...:.:.:.:.:.:.|  |::|.:|.|:.|:|:||.||:|||...:|:|||.|..
  Rat   173 FHAREWISPAFCQWFVREAVRTYNQEIHMKQLLDELDFYVLPVVNIDGYVYTWTKDRMWRKTRST 237

  Fly   235 NGYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIR 299
            ..    ...|.|:|.||||:..|...|.: ..||...:.|..|.:|.|..:|.:|:.: ....|:
  Rat   238 MA----GSSCLGVDPNRNFNAGWCEVGAS-RSPCSETYCGPAPESEKETKALADFIRN-NLSTIK 296

  Fly   300 SYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAA 364
            :|:..|:|.|.:|.||.: :.:.|.|||::..:....:...|.::|:.:|||......|..:|.:
  Rat   297 AYLTIHSYSQMMLYPYSY-DYKLPENYEELNALVKGAAKELATLHGTKYTYGPGATTIYPAAGGS 360

  Fly   365 KDWAY--GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLKALVNKAAE 417
            .||:|  |:|   ::.|.||||.|.|||.||.:||.:...|....:|.:.|...|
  Rat   361 DDWSYDQGIK---YSFTFELRDTGFFGFLLPESQIRQTCEETMLAVKYIANYVRE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	18/83 (22%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	102/302 (34%)
Cpb1	NP_036665.2	Propep_M14	33..102	CDD:396700	18/85 (21%)
Cpb1	NP_036665.2	M14_CPB	112..410	CDD:349443	102/307 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3014
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800