DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and suro-1

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_492177.2	Gene:	suro-1 / 172557	WormBaseID:	WBGene00011235	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	432	Identity:	114/432 - (26%)
Similarity:	204/432 - (47%)	Gaps:	70/432 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HEHISVHFLNEL---------------GAVGNKYNVIV--GPLFHRALEKTLKFLEIVYEVIVDD 97
            |:..|:|.:.:|               .::.:|.:::|  |. ..|.|.:.|.|..:...:.|.|
Worm    42 HDEQSLHLIKQLQLNDFKYDLDFWKSPSSISDKADIMVKRGK-SERMLRQILSFANVTVSMSVPD 105

  Fly    98 LQKLI-------DESSVGDDSQMEW-------ETYHTLDTI---------YDWIDQECAAH---- 135
            ::|||       .:|.:|..|..:|       ::...||..         |.:.|....|.
Worm   106 VEKLIMRNEGTTSKSHLGFGSLSKWLHDDPILDSEPDLDLTKVGALKKAKYPFGDYASYADMVKY 170

  Fly   136 ----DFLECKV-----IGQSYEGRDIKSIRLSKRSGNK--AIFLEGNIHAMEWISSATVTFLLNQ 189
                :|...::     ||.::||:.|:.:::..||.:|  |::::|||||.||.||.|..:.:||
Worm   171 MRTIEFYYPRIAKIVRIGATHEGKPIEGLKIGARSSHKKRAVWVDGNIHAREWASSHTALYFINQ 235

  Fly   190 LIN--SEDPEMQRLSEEYDWIVVPMVNPDGFVYTH----EVERLWRKNRRPNGYRNE--SGD--C 244
            |::  .:|.::....:..|:.:||.:||||:.||.    ...|||||||.|...|..  .|:  |
Worm   236 LVSEYGKDAQITNYVDTLDFYIVPCLNPDGYEYTRTSPIPTVRLWRKNRSPELCRPSLWGGEKCC 300

  Fly   245 YGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFE-DGYIRSYMAYHAYG 308
            .|:|:||||.:||...|.:. |||.:.:.|||..:|.|..:::||:::.| ...:.:::..|:|.
Worm   301 RGVDLNRNFRFHWAERGSSY-EPCSNIYHGEEVFSEPETRAVRNFLATPEMKDRVDAFVTLHSYA 364

  Fly   309 QYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAYGVKK 373
            |..:.||.|....:|.:..::::.|....:..:.|||:.:..|.........:|.:.|||.....
Worm   365 QLWIYPYSHEEQNYPEDIGELRKTARKAINRLSRVYGTNYRMGTGADTLSPAAGGSDDWAKSALN 429

  Fly   374 IPFTCTVELRDKGTF--GFFLPSNQITEVGLEVTAGLKALVN 413
            :.:...:|||.:...  ||.|...::....:|...|.:.:|:
Worm   430 VKYVYLIELRPQMELSNGFILHKKELIPTAVETFEGFREVVD 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	16/77 (21%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	94/333 (28%)
suro-1	NP_492177.2	Propep_M14	39..110	CDD:280416	14/68 (21%)
		M14_CP_A-B_like	161..473	CDD:199844	90/312 (29%)
		ShK	620..657	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820