DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	120/460 - (26%)
Similarity:	217/460 - (47%)	Gaps:	58/460 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIHEHIS---VHFLNELGAVGN 66
            ||.:.|..::|..|:    ...:..|:::::...||.|:.::.::.|...   ..|.:....|..
Worm     2 ILRVILALLIAVHSS----CQEHGAFKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVNG 62

  Fly    67 KYNVIVGP----LFHRALEKTLKFLEIVYEVIVDDLQKLIDE--------------------SSV 107
            ..:::|.|    .|.:.|||.    ...::|.:|||.||:.|                    ..|
Worm    63 TVDIMVAPEHTDQFRQYLEKH----GYTFQVAIDDLHKLLIEKEGNLSTHSNDDAFFLKRLHDDV 123

  Fly   108 GDDSQMEWETYHTLDTIYDWIDQECA-AHDFLECKVIGQSYEGRDIKSIRLSKRSGNKAI-FLEG 170
            |..|::....|::...:..|:::... ..|..:...:|.:.|||||..::..|.:.:|.| .::.
Worm   124 GFHSRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDILGLKFGKDTPDKKIVVIDA 188

  Fly   171 NIHAMEWISSATVTFLLNQLIN--SEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVE-----RLW 228
            .|||.||.:..|.::.:|.::|  .|||::|...:.....::|::||||:.||...:     |:|
Worm   189 GIHAREWAAIHTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNPRARMW 253

  Fly   229 RKNRRP-----NGYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQN 288
            ||:|.|     :|.||..  |.|:|:|||||:.:...|.: ..||...:.|....:|.|..:...
Worm   254 RKSRSPKACAFDGVRNSC--CMGVDLNRNFDFRFSEIGAS-RYPCSEIYHGPSAFSEPESKAYSQ 315

  Fly   289 FVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGAS 353
            |::|.: |.:.:|:..|:|.|..:..|.|....:.|:.|:.:|:||........:||:.:.:|..
Worm   316 FLTSLK-GRLEAYITLHSYSQLWIYSYSHRKFTYAPDIEETRRVAAKAVQELGRMYGTKYRHGTG 379

  Fly   354 GLLNYVVSGAAKDWAYGVKKIPFTCTVELRD--KGTF---GFFLPSNQITEVGLEVTAGLKALVN 413
            ..:.|..||.:.|||....||.::.|:|||.  :|..   ||.|..||:.....|..||:..:::
Worm   380 PEIIYAFSGGSTDWAKETLKIKYSYTIELRPGYEGIIEWNGFVLDKNQLIPTAKETWAGVTVVLD 444

  Fly   414 KAAEE 418
            :...:
Worm   445 EVTNQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	18/76 (24%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	92/315 (29%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	19/73 (26%)
		M14_CP_A-B_like	134..446	CDD:349433	92/315 (29%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930