DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12374 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	115/427 - (26%)
Similarity:	208/427 - (48%)	Gaps:	43/427 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FRIYQLTIETNLQMEELKKIHEHISVHFLNELGAVGNK---YNVIVGPLFHRALEKTLKFLEIVY 91
            |.:|:|..::....:.:::::::.:.|.||......:|   ::|:|.....:.....|:..:|.|
Worm    23 FAVYRLLPKSQTDFQAIQRLYKNATDHDLNFWKTGKDKHGFWDVMVDMKNSKYFLDFLQVNDISY 87

  Fly    92 EVIVDDLQKLI-----------------DESSVGDDSQMEWETYHTLDTIYDWIDQECAAH-DFL 138
            ...:||::.||                 |:||   .:..::.||.:...:.||:.|....: ..:
Worm    88 IKTIDDVEGLITKHENNKTLSNMFPRLWDDSS---SAHYDFHTYGSYQRMTDWMKQLVVKYPKMV 149

  Fly   139 ECKVIGQSYEGRDIKSIRLSKRSGNKAIF-LEGNIHAMEWISSATVTFLLNQLIN-SEDPEMQRL 201
            :...||::.|||:|..:.:...|..|.|| ::|.|||.||.:..|..|.::||.: :.:|.:::|
Worm   150 QYISIGKTTEGRNIDGVEIGGDSRTKKIFWIDGGIHAREWAAPHTALFFIHQLTSRANEPGIKKL 214

  Fly   202 SEEYDWIVVPMVNPDGFVYTHEVE----RLWRKNRRPNGYRNE----SGDCYGIDMNRNFDYHWG 258
            ..|..::|||.:||||:.:|....    |||||||.....|.:    :..|.|:|:|||||:|:.
Worm   215 LNEITFVVVPCLNPDGYEFTRSSTNPHVRLWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFDFHFR 279

  Fly   259 GAGWNIDEPCDHWFGGEEPNTEVEIISLQN-FVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEF 322
            .:|.: |:||...:.|..|.:|.|..:::: .:|....|...:|:..|.|.|..:.||||....:
Worm   280 ESGTS-DDPCSEIYQGPSPFSEPEAKAVRDALLSQRYKGRTDAYITLHTYSQIWIHPYGHKKDAY 343

  Fly   323 PPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAYGVKKIPFTCTVELR--DK 385
            |.:.:.:..:....:.|...|||:.:..|:.....|..||.::|||....|:.|...:|||  :|
Worm   344 PGDIKDLYEVGKKAAQALKRVYGTKYVVGSGADTLYPASGGSEDWAKHEAKVKFVYLLELRPDEK 408

  Fly   386 GTFGFFLPSNQITEVGLEVTAGLKALVNKAAEEGIFD 422
            ...||.|...::.....|...|::.:.     |.:.|
Worm   409 NWDGFILDEKELIPTARETWEGVRVVA-----EAVLD 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	14/89 (16%)
CG12374	NP_610819.1	M14_CP_A-B_like	118..415	CDD:199844	93/310 (30%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	11/66 (17%)
		M14_CP_A-B_like	128..438	CDD:349433	94/315 (30%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930