Protein Alignment CG12374 and CPB1

DIOPT Version :10

• Sequence 1: NP_610819.1
• Gene: CG12374 / 36410
• FlyBaseID: FBgn0033774
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001862.2
• Gene: CPB1 / 1360
• HGNCID: 2299
• Length: 417
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 125/446 - (28%)
• Similarity: 214/446 - (47%)
• Gaps: 64/446 - (14%)

  Fly     3 LPILLITLVAMVAAKSAPGRMAARYDHF---RIYQLTIE--------------TNLQM---EELK 47
            |.:|::..||:.:|....       :||   :::::.:|              |.:..   :.:.
Human     2 LALLVLVTVALASAHHGG-------EHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVT 59

  Fly    48 KIHEHISVHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDESSVGDDSQ 112
            :|..|.:|.|     .|..:..|.|        |..||..|:.|:|::.:|:.:::...   ||:
Human    60 QIKPHSTVDF-----RVKAEDTVTV--------ENVLKQNELQYKVLISNLRNVVEAQF---DSR 108

  Fly   113 M-----EWETYHTLDTIYDWIDQECAAHDFLECK-VIGQSYEGRDIKSIRLSKRSGNK-AIFLEG 170
            :     .:|.|:..:||..|..|....:..|..: |||.::|||.|..:::.|...|| |||::.
Human   109 VRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDC 173

  Fly   171 NIHAMEWISSATVTFLLNQLINSEDPEMQ--RLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRR 233
            ..||.||||.|...:.:.:.:.:...|:|  .|.::.|:.|:|::|.||::||....|.|||.|.
Human   174 GFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRS 238

  Fly   234 PNGYRNESGDCYGIDMNRNFDYHWG--GAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDG 296
                .:....|.|.|.|||||..|.  ||..|   |||..:.|....:|.|..:|.:|:.: :..
Human   239 ----THTGSSCIGTDPNRNFDAGWCEIGASRN---PCDETYCGPAAESEKETKALADFIRN-KLS 295

  Fly   297 YIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVS 361
            .|::|:..|:|.|.::.||.:: .:...|..::..:|.|.....|.::|:.:|||......|..:
Human   296 SIKAYLTIHSYSQMMIYPYSYA-YKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAA 359

  Fly   362 GAAKDWAYGVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLKALVNKAAE 417
            |.:.||||. :.|.::.|.||||.|.:||.||.:||.....|....:|.:.:...|
Human   360 GGSDDWAYD-QGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLE 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	33..104	CDD:460505	16/87 (18%)
		M14_CP_A-B_like	118..413	CDD:349433	98/300 (33%)
CPB1	NP_001862.2	Propep_M14	28..104	CDD:460505	16/88 (18%)
		M14_CPB	114..413	CDD:349443	99/308 (32%)