Protein Alignment CG12374 and CPA3

DIOPT Version :10

• Sequence 1: NP_610819.1
• Gene: CG12374 / 36410
• FlyBaseID: FBgn0033774
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001861.2
• Gene: CPA3 / 1359
• HGNCID: 2298
• Length: 417
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 118/436 - (27%)
• Similarity: 218/436 - (50%)
• Gaps: 63/436 - (14%)

  Fly     3 LPILLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQ---MEELKKIHE----------HIS 54
            ||:.||.....:|        ..|:|..:::::..:...|   :::|.|.:|          |::
Human     5 LPVGLIATTLAIA--------PVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVA 61

  Fly    55 VHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDES-SVGDD--SQMEWE 116
            .:.:.:. .|..|.:        :|::..|...::.||:::.|||:.|::. .|.:|  .:..:.
Human    62 ANMMVDF-RVSEKES--------QAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYA 117

  Fly   117 TYHTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIKSIRL-SKRSGNKAIFLEGNIHAMEWIS 179
            .|:..:.|..|.::....:..:..:: ||.:.|...:..::: .|....||||.:..|||.||:|
Human   118 KYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVS 182

  Fly   180 ---------SATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPN 235
                     .||.|:..|::       |.:|.:..::.::|:.|.||::::....|:|||||.
Human   183 PAFCQWFVYQATKTYGRNKI-------MTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRS-- 238

  Fly   236 GYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRS 300
              :|::..|.|.|:||||:..|.... |.::||...:.|..|.:|.|..::.||:.|..: .|:.
Human   239 --KNQNSKCIGTDLNRNFNASWNSIP-NTNDPCADNYRGSAPESEKETKAVTNFIRSHLN-EIKV 299

  Fly   301 YMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAK 365
            |:.:|:|.|.:|.|||:: ::.|||:|.:.::|...:|..:..|.:.:.||......|.:||::.
Human   300 YITFHSYSQMLLFPYGYT-SKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSL 363

  Fly   366 DWAY--GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLK 409
            ||||  |:|   .|...||||||.|||.||.::|.....|....:|
Human   364 DWAYDLGIK---HTFAFELRDKGKFGFLLPESRIKPTCRETMLAVK 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	33..104	CDD:460505	15/83 (18%)
		M14_CP_A-B_like	118..413	CDD:349433	94/305 (31%)
CPA3	NP_001861.2	Propep_M14	27..103	CDD:460505	15/84 (18%)
		M14_CPB	114..413	CDD:349443	94/310 (30%)