Protein Alignment CG12374 and CPA3

DIOPT Version :9

• Sequence 1: NP_610819.1
• Gene: CG12374 / 36410
• FlyBaseID: FBgn0033774
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001861.2
• Gene: CPA3 / 1359
• HGNCID: 2298
• Length: 417
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 118/436 - (27%)
• Similarity: 218/436 - (50%)
• Gaps: 63/436 - (14%)

  Fly     3 LPILLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQ---MEELKKIHE----------HIS 54
            ||:.||.....:|        ..|:|..:::::..:...|   :::|.|.:|          |::
Human     5 LPVGLIATTLAIA--------PVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVA 61

  Fly    55 VHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKLIDES-SVGDD--SQMEWE 116
            .:.:.:. .|..|.:        :|::..|...::.||:::.|||:.|::. .|.:|  .:..:.
Human    62 ANMMVDF-RVSEKES--------QAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYA 117

  Fly   117 TYHTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIKSIRL-SKRSGNKAIFLEGNIHAMEWIS 179
            .|:..:.|..|.::....:..:..:: ||.:.|...:..::: .|....||||.:..|||.||:|
Human   118 KYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVS 182

  Fly   180 ---------SATVTFLLNQLINSEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPN 235
                     .||.|:..|::       |.:|.:..::.::|:.|.||::::....|:|||||.
Human   183 PAFCQWFVYQATKTYGRNKI-------MTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRS-- 238

  Fly   236 GYRNESGDCYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRS 300
              :|::..|.|.|:||||:..|.... |.::||...:.|..|.:|.|..::.||:.|..: .|:.
Human   239 --KNQNSKCIGTDLNRNFNASWNSIP-NTNDPCADNYRGSAPESEKETKAVTNFIRSHLN-EIKV 299

  Fly   301 YMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAK 365
            |:.:|:|.|.:|.|||:: ::.|||:|.:.::|...:|..:..|.:.:.||......|.:||::.
Human   300 YITFHSYSQMLLFPYGYT-SKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSL 363

  Fly   366 DWAY--GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLK 409
            ||||  |:|   .|...||||||.|||.||.::|.....|....:|
Human   364 DWAYDLGIK---HTFAFELRDKGKFGFLLPESRIKPTCRETMLAVK 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	34..104	CDD:280416	15/82 (18%)
		M14_CP_A-B_like	118..415	CDD:199844	94/305 (31%)
CPA3	NP_001861.2	Propep_M14	28..102	CDD:280416	15/82 (18%)
		M14_CPB	114..413	CDD:199852	94/310 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750