Protein Alignment CG12374 and CPA2

DIOPT Version :10

• Sequence 1: NP_610819.1
• Gene: CG12374 / 36410
• FlyBaseID: FBgn0033774
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001860.2
• Gene: CPA2 / 1358
• HGNCID: 2297
• Length: 419
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 118/394 - (29%)
• Similarity: 207/394 - (52%)
• Gaps: 38/394 - (9%)

  Fly    37 IETNLQMEELKKIHEHISVHFLNELGAVGNKYNVIVGPLFHRALEKTLKFLEIVYEVIVDDLQKL 101
            |:..||:|    ..||:.:.|.......|...:|.|..:..:|::..|:...|.|.::::|:|.|
Human    38 IKNLLQLE----AQEHLQLDFWKSPTTPGETAHVRVPFVNVQAVKVFLESQGIAYSIMIEDVQVL 98

  Fly   102 IDESSVGDDSQM------------EWETYHTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIK 153
            :|:    ::.:|            .:..||||:.|...:|...|.|..|..|| ||.|:|.|.:.
Human    99 LDK----ENEEMLFNRRRERSGNFNFGAYHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMN 159

  Fly   154 SIRLSKRSGNKAIFLEGNIHAMEWISSATVTFLLNQLIN--SEDPEMQRLSEEYDWIVVPMVNPD 216
            .::.|......||:|:..|||.||::.||..:..|::::  .:||.:..:.:..|..::|:.|||
Human   160 VLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKIVSDYGKDPSITSILDALDIFLLPVTNPD 224

  Fly   217 GFVYTHEVERLWRKNRRPNGYRNESGD-CYGIDMNRNFDYHWGGAGWNIDEPCDHWFGGEEPNTE 280
            |:|::....|:|||.|     ...||. |.|:|.|||:|..:||.|.: ..||...:.|...|:|
Human   225 GYVFSQTKNRMWRKTR-----SKVSGSLCVGVDPNRNWDAGFGGPGAS-SNPCSDSYHGPSANSE 283

  Fly   281 VEIISLQNFVSSFEDGYIRSYMAYHAYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYG 345
            ||:.|:.:|:.|  .|.:::::..|:|.|.::.|||:..|:. .:::::..:|...:.:...::|
Human   284 VEVKSIVDFIKS--HGKVKAFITLHSYSQLLMFPYGYKCTKL-DDFDELSEVAQKAAQSLRSLHG 345

  Fly   346 STFTYGASGLLNYVVSGAAKDWA--YGVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGL 408
            :.:..|....:.|..||.:.||:  ||:|   ::...||||.|.:||.||:.||.....|...||
Human   346 TKYKVGPICSVIYQASGGSIDWSYDYGIK---YSFAFELRDTGRYGFLLPARQILPTAEETWLGL 407

  Fly   409 KALV 412
            ||::
Human   408 KAIM 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12374	NP_610819.1	Propep_M14	33..104	CDD:460505	17/66 (26%)
		M14_CP_A-B_like	118..413	CDD:349433	99/301 (33%)
CPA2	NP_001860.2	Propep_M14	28..102	CDD:460505	18/71 (25%)
		M14_CPA	118..417	CDD:349442	99/306 (32%)