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Protein Alignment CG12374 and CPA1

DIOPT Version :9

Sequence 1:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001859.1	Gene:	CPA1 / 1357	HGNCID:	2296	Length:	419	Species:	Homo sapiens

Alignment Length:	434	Identity:	132/434 - (30%)
Similarity:	227/434 - (52%)	Gaps:	50/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPILLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIH--EHISVHFLNELGAVG 65
            |.:|.:.|.|:...:...|.        ::.::::....|::::|::.  ||:.:.|.......|
Human     4 LLVLSVLLGAVFGKEDFVGH--------QVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPG 60

  Fly    66 NKYNVIVGPLFHRALEKTLKFLE---IVYEVIVDDLQKLIDE---------SSVGDDSQMEWETY 118
            :..:|.| |.  .:::....|||   |.||.:::|:|.|:||         |.........:.||
Human    61 SPIDVRV-PF--PSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATY 122

  Fly   119 HTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIKSIRLSKRSGNK--AIFLEGNIHAMEWISS 180
            |||:.|||::|...|.:..|..|: ||.:||||.|..::.| ..|:|  ||:::..||:.||::.
Human   123 HTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFS-TGGSKRPAIWIDTGIHSREWVTQ 186

  Fly   181 ATVTFLLNQLIN--SEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNESGD 243
            |:..:...::..  .:|.....:.:..|..:..:.|||||.:||...|:|||.|     .:.:|.
Human   187 ASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTR-----SHTAGS 246

  Fly   244 -CYGIDMNRNFDYHWG--GAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRSYMAYH 305
             |.|:|.|||:|..:|  ||..|   ||...:.|:..|:|||:.|:.:||.  :.|.|:::::.|
Human   247 LCIGVDPNRNWDAGFGLSGASSN---PCSETYHGKFANSEVEVKSIVDFVK--DHGNIKAFISIH 306

  Fly   306 AYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAY- 369
            :|.|.::.|||: .||..|:.:::.:::.|...|.|.:||:.|.||:.....|..||:..||.|
Human   307 SYSQLLMYPYGY-KTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYS 370

  Fly   370 -GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLKALV 412
             |:|   ::.|.||||.|.:||.||::||.....|....|..::
Human   371 QGIK---YSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIM 411

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.