Protein Alignment Dgkepsilon and DGKE

DIOPT Version :9

• Sequence 1: NP_001286362.1
• Gene: Dgkepsilon / 36408
• FlyBaseID: FBgn0020930
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_016880732.1
• Gene: DGKE / 8526
• HGNCID: 2852
• Length: 691
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 199/664 - (29%)
• Similarity: 296/664 - (44%)
• Gaps: 175/664 - (26%)

  Fly    22 ILFAFCRSLLSEDFVSTF------------------KTRHSWKSIKVLEQACFCNVC--EILLTP 66
            ||:..| |:|...|: ||                  |::|.|:...:..|..:|.||  .||
Human    23 ILWTLC-SVLLPVFI-TFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCCVCAQHIL--- 82

  Fly    67 SAGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRNESSV----RHLWVHGNLPMGVHCADCNEE 127
             .|.|||||||  .....|.|:||:.::||:..|:|::.|    .|.|:.||:|:..:|..|.::
Human    83 -QGAFCDCCGL--RVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQ 144

  Fly   128 VDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSFVAA--RTRDSMRL 190
                ....|.|..:||.|||:..|::|...:...|.||.||||::|.|| |::.:  :.|...:.
Human   145 ----CGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPP-SYLTSINQMRKDKKT 204

  Fly   191 HLASITPPDIENWEPLIVIANTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASP 255
            ....:.....:.|.|||::||::||::.|..:|...|..|:|:||.::....|..|||.......
Human   205 DYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPY 269

  Fly   256 RPCRILVAGGDGTIGWVLNTI-------------------------------------------- 276
            ...|:||.|||||:||||:.:
Human   270 YSARVLVCGGDGTVGWVLDAVDDMKIKVLVFKNYYRRTSKINILYIYIYIWVLLLFCCCCCFFLR 334

  Fly   277 YTLNIKPQ--------------------------------------------------------- 284
            |:|.:.|:
Human   335 YSLALSPRLECSGADTANCNLHFSGSSHPPTSAYKVAETIGVRYHAWLIFVFFVETGFHHVAWAA 399

  Fly   285 ---------------------------PSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIR 322
                                       |.||::|||||||||..||||......:...::||::.
Human   400 VKLLGSSDPPTLASQSAGITWGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVM 464

  Fly   323 RARSVNLDRFDLQI-EKLHYRLPIQRHPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRI 386
            .|..:.|||:.:|: .|.:|.|   |.| |...:.||||||.||.:..|||..||....|.||||
Human   465 EADGIKLDRWKVQVTNKGYYNL---RKP-KEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRI 525

  Fly   387 FNKLLYFTFGTQQVMQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCKLCELSNANG 451
            .||.:|..:||:..:...|:.:.:|:.|.||.:.|.||.|:.::.|||..||.||:|.|  ....
Human   526 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWE--GMGD 588

  Fly   452 EVRIVNSISDGMMEVFGIVSSFHIAQLQCNISKPVRIGQAKQIRLQVK-ETVPMQADGEPWMQSP 515
            |...:....||::||.|:..|||.||:|..::.|.|||||..:||.:| ..:|||.|||||.|.|
Human   589 ETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGP 653

  Fly   516 ADIRLSSRSQARVL 529
            ..:.::.::.|.:|
Human   654 CTVTITHKTHAMML 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	17/56 (30%)
		LCB5	207..519	CDD:224513	132/441 (30%)
		DAGKc	207..331	CDD:214487	51/251 (20%)
		DAGK_acc	355..510	CDD:279003	67/155 (43%)
DGKE	XP_016880732.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5130
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2705
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2294
Isobase	1	0.950	-	0	Normalized mean entropy	S4568
OMA	1	1.010	-	-		QHG60285
OrthoDB	1	1.010	-	-		D1275907at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		oto88581
orthoMCL	1	0.900	-	-		OOG6_106579
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790