Protein Alignment Dgkepsilon and Dgke

DIOPT Version :10

• Sequence 1: NP_725228.1
• Gene: Dgkepsilon / 36408
• FlyBaseID: FBgn0020930
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_062378.1
• Gene: Dgke / 56077
• MGIID: 1889276
• Length: 564
• Species: Mus musculus
• Alignment Length: 538
• Identity: 190/538 - (35%)
• Similarity: 293/538 - (54%)
• Gaps: 48/538 - (8%)

  Fly    22 ILFAFCRSLLSEDFVSTF-----------------KTRHSWKSIKVLEQACFCNVC--EILLTPS 67
            :|:..| |:|...|::.:                 |::|.|:...:.....:|.||  .||
Mouse    21 VLWTLC-SVLLPVFITLWCSLQRSRRQLHRRDIFRKSKHCWRDTDLFSHPTYCCVCAQHIL---- 80

  Fly    68 AGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRNE---SSVRHLWVHGNLPMGVHCADCNEEVD 129
            .|.|||||||  .....|.::.|:.:.||:..|:|:   .::.|.|:.||:|:..:|..|.::
Mouse    81 QGAFCDCCGL--RVDEGCLKKVDKRFPCKEIMLKNDKAADAMPHHWIRGNVPLCSYCVFCRQQ-- 141

  Fly   130 HHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSFVAA--RTRDSMRLHL 192
              ..:.|.|..:||.|||:..|::|...:...|.||.|||:::|.|| |::.:  :.|.....:.
Mouse   142 --CGSQPKLCDYRCIWCQKTVHDECMRGSLRSEKCDFGEFRNLIIPP-SYLTSINQMRKDKNTNY 203

  Fly   193 ASITPPDIENWEPLIVIANTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRP 257
            ..:.....:.|.|||::||::||::.|..:|...:..|:|:||.::....|..|||.........
Mouse   204 EGLASKFGKQWTPLIILANSRSGTNMGEGLLGEFKILLNPVQVFDVTKTPPIKALQLCTLLPYYS 268

  Fly   258 CRILVAGGDGTIGWVLNTIYTLNIKPQ----PSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKIL 318
            .|:||.|||||:||||:.|..:.||.|    |.||::|||||||||..||||......:...::|
Mouse   269 VRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVL 333

  Fly   319 RSIRRARSVNLDRFDLQI-EKLHYRLPIQRHPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLL 382
            |::..|..:.|||:.:|: .|.:|.|   |.| |...:.||||||.||.:..|||..||....|.
Mouse   334 RNVMEADGIKLDRWKVQVTNKGYYNL---RKP-KEFTMNNYFSVGPDALMALNFHAHREKAPSLF 394

  Fly   383 SSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCKLCELS 447
            ||||.||.:|..:||:..:...|:.:.:|:.|.||.:.|:||.|:.::.|||..||.||:|.|
Mouse   395 SSRILNKAVYLFYGTKDCLVQECKDLNKKIELELDGERVELPNLEGIIVLNIGYWGGGCRLWE-- 457

  Fly   448 NANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCNISKPVRIGQAKQIRLQVK-ETVPMQADGEPW 511
            ....|...:....||::|:.|:..|||.||:|..::.|.|||||..:||.:| ..:|||.|||||
Mouse   458 GMGDETYPLARHDDGLLEIVGVYGSFHCAQIQVKLANPFRIGQAHTVRLTLKCSMMPMQVDGEPW 522

  Fly   512 MQSPADIRLSSRSQARVL 529
            .|.|..:.::.::.|.:|
Mouse   523 AQGPCTVTITHKTHALML 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_725228.1	C1_DGKepsilon_typeIII_rpt1	40..96	CDD:410351	18/57 (32%)
		C1_DGK_rpt2	108..167	CDD:410355	19/58 (33%)
		DAGKc	207..331	CDD:214487	51/127 (40%)
		DAGK_acc	356..510	CDD:459866	66/154 (43%)
Dgke	NP_062378.1	C1_DGKepsilon_typeIII_rpt1	55..108	CDD:410351	19/58 (33%)
		C1_DGKepsilon_typeIII_rpt2	122..186	CDD:410403	23/67 (34%)
		DAGKc	218..346	CDD:214487	51/127 (40%)
		DAGKa	366..521	CDD:214486	66/156 (42%)