DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgkepsilon and Dgke

DIOPT Version :9

Sequence 1:	NP_001286362.1	Gene:	Dgkepsilon / 36408	FlyBaseID:	FBgn0020930	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001381287.1	Gene:	Dgke / 497978	RGDID:	1560914	Length:	567	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	187/506 - (36%)
Similarity:	283/506 - (55%)	Gaps:	33/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KTRHSWKSIKVLEQACFCNVC--EILLTPSAGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRN 102
            |::|.|:...:.....:|.||  .||    .|.|||||||  .....|.::.|:.:.||:..|:|
  Rat    55 KSKHCWRDTDLFSHPTYCCVCAQHIL----QGAFCDCCGL--RVDEGCLKKVDKRFPCKEIMLKN 113

  Fly   103 ES----SVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEA 163
            :|    ::.|.|:.||:|:..:|..|.::    ..:.|.|..:||.|||:..|::|...:...|.
  Rat   114 DSRAADAMPHHWIRGNVPLCTYCVICRQQ----CGSQPKLCDYRCVWCQQTVHDECMRGSLKSEK 174

  Fly   164 CDLGEFKDMIFPPYSFVAA--RTRDSMRLHLASITPPDIENWEPLIVIANTKSGSSTGANVLSLL 226
            ||.||||::|.|| |::.:  :.|.....:...:.....:.|.|||::||::||::.|..:|...
  Rat   175 CDFGEFKNLIIPP-SYLTSINQMRKDKNTNYEVLASKFGKQWTPLIILANSRSGTNMGEGLLGEF 238

  Fly   227 RGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKPQ----PSV 287
            :..|:|:||.::....|..|||..........|:||.|||||:||||:.|..:.||.|    |.|
  Rat   239 KMLLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEV 303

  Fly   288 AIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQI-EKLHYRLPIQRHPTK 351
            |::|||||||||..||||......:...::||::..|..:.|||:.:|: .|.:|.|   |.| |
  Rat   304 AVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYSL---RKP-K 364

  Fly   352 TIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTLYL 416
            ...:.||||:|.||.:..|||..||....|.||||.||.:|..:||:..:...|:.:.:|:.|.|
  Rat   365 EFTMNNYFSIGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTRDCLVQECKDLNKKIELEL 429

  Fly   417 DNKPVQLPELQALVFLNIDSWGAGCKLCELSNANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCN 481
            |.:.|:||.|:.::.|||..||.||:|.|  ....|...:....||::||.|:..|||.||:|..
  Rat   430 DGERVELPNLEGVIVLNIGYWGGGCRLWE--GVGDETYPLARHDDGLLEVVGVYGSFHCAQIQVK 492

  Fly   482 ISKPVRIGQAKQIRLQVK---ETVPMQADGEPWMQSPADIRLSSRSQARVL 529
            ::.|.|||||..:||.:|   ..:|||.|||||.|.|..:.::.::.|.:|
  Rat   493 LANPFRIGQAHTVRLTLKCSRMPMPMQVDGEPWAQGPCTVTITHKTHALML 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	17/56 (30%)
		LCB5	207..519	CDD:224513	131/319 (41%)
		DAGKc	207..331	CDD:214487	51/127 (40%)
		DAGK_acc	355..510	CDD:279003	66/157 (42%)
Dgke	NP_001381287.1	C1_DGKepsilon_typeIII_rpt1	55..108	CDD:410351	19/58 (33%)
		C1_DGKepsilon_typeIII_rpt2	123..187	CDD:410403	24/67 (36%)
		DAGKc	219..347	CDD:214487	51/127 (40%)
		DAGKa	367..524	CDD:214486	66/158 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I4952
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2262
OMA	1	1.010	-	-		QHG60285
OrthoDB	1	1.010	-	-		D1275907at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		oto95714
orthoMCL	1	0.900	-	-		OOG6_106579
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5376
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.940