Protein Alignment Dgkepsilon and Dgkh

DIOPT Version :10

• Sequence 1: NP_725228.1
• Gene: Dgkepsilon / 36408
• FlyBaseID: FBgn0020930
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_036014587.1
• Gene: Dgkh / 380921
• MGIID: 2444188
• Length: 1246
• Species: Mus musculus
• Alignment Length: 820
• Identity: 167/820 - (20%)
• Similarity: 252/820 - (30%)
• Gaps: 362/820 - (44%)

  Fly    36 VSTFKTRHSWKSIKVLEQAC------FCNVCEILLT--PSAGLFCDCCGLCTHATPPCQRRADRE 92
            |..|...|:|       .||      |||||...|:  .|.||.|:.|....|..  |..||..
Mouse   190 VEHFSGMHNW-------YACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKR--CAVRATN- 244

  Fly    93 YRCKDKW----------LRNESSVR--HLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAW 145
             .|  ||          :.:|..|.  |.|:.||||:...||.|    |....:...|..|:|.|
Mouse   245 -NC--KWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVC----DKTCGSVLRLQDWKCLW 302

  Fly   146 CQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSFVAARTRDSMRLHLASITPPDIENWEPLIVIA 210
            |:...|..|  :......|.||:.|..|.||   :|..:.||.....|:.:    ....||:|..
Mouse   303 CKTMVHTAC--KDVYHPVCPLGQCKVSIIPP---IALNSTDSDGFCRATFS----FCVSPLLVFV 358

  Fly   211 NTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNT 275
            |:|||.:.|...|...:..|:|.||.:|.:.||...|:...|..  ..||||.||||::||||:.
Mouse   359 NSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFD--NFRILVCGGDGSVGWVLSE 421

  Fly   276 IYTLNIKPQPSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLH 340
            |..||:..|..:.::||||||||:||||||..........:||..:.||.:..|||:.:...:|
Mouse   422 IDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYEL- 485

  Fly   341 YRLP------------------------IQRHPTKTIH--------------------------- 354
             :||                        :..|.||.::
Mouse   486 -KLPAKSSLLPEPVAATEEFYMTIYEDSVANHLTKIVNSDEHAVVISSAKILCETVKDFVAKVEK 549

  Fly   355 ----------------------------------------------------------------- 354
                                                                             
Mouse   550 AQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHADSQASRVPPGIGPAIPEEDTVESASDESLG 614

  Fly   355 ----------------------------------------------------------------- 354
                                                                             
Mouse   615 ESKDQLVNDIGKPSSQKAVKPREIMLRANSLKKAVRQVIEEAEKVMDEPAVQPSEPVSPSCDYDT 679

  Fly   355 ----------------------------------------------------------------- 354
                                                                             
Mouse   680 ETDEAKEDDAKESLSAKTTSQSPDAQASCGHPQTDSVAGPAMATTKENLPVLNTRIICPGLRAGL 744

  Fly   355 ------------------------------------------VYNYFSVGVDAYITYNFHKTRES 377
                                                      :.|||.:|:||.|:..|:..||.
Mouse   745 AASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREE 809

  Fly   378 RFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTL-----------YLDNKPVQLPELQALVF 431
            ......||..|.:.|...||::::|...:::|:::.|           ..|.:.:.||.||.:..
Mouse   810 HPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLEGISFLSSFCDQCDGQYIPLPSLQGIAV 874

  Fly   432 LNIDSWGAGCKLCELSNANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCNISKPV-----RIGQA 491
            |||.|:..|..... .....::....|..|.::||..:..|..:|     :|:.:     ||.|.
Mouse   875 LNIPSYAGGTNFWG-GTKEDDIFAAPSFDDKILEVVAVFDSVQMA-----VSRVIKLQHHRIAQC 933

  Fly   492 KQIRLQV--KETVPMQADGEPWMQSPADIRLSSRSQARVL 529
            :.:::.:  .|.||:|.|||.|:|.|..|::..:::|::|
Mouse   934 RTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQML 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_725228.1	C1_DGKepsilon_typeIII_rpt1	40..96	CDD:410351	19/63 (30%)
		C1_DGK_rpt2	108..167	CDD:410355	18/58 (31%)
		DAGKc	207..331	CDD:214487	51/123 (41%)
		DAGK_acc	356..510	CDD:459866	45/171 (26%)
Dgkh	XP_036014587.1	PH_DGK_type2	88..184	CDD:270093
		C1_DGKeta_rpt1	168..253	CDD:410398	24/75 (32%)
		C1_DGKeta_rpt2	264..325	CDD:410444	21/66 (32%)
		DAGKc	355..477	CDD:214487	51/123 (41%)
		DAGKa	786..954	CDD:214486	45/173 (26%)
		SAM_DGK-eta	1174..1238	CDD:188975