DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgkepsilon and DGKQ

DIOPT Version :9

Sequence 1:	NP_001286362.1	Gene:	Dgkepsilon / 36408	FlyBaseID:	FBgn0020930	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001338.2	Gene:	DGKQ / 1609	HGNCID:	2856	Length:	942	Species:	Homo sapiens

Alignment Length:	383	Identity:	130/383 - (33%)
Similarity:	203/383 - (53%)	Gaps:	39/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CYTRADSMEACDLGEFKDMIFPPYSFVAARTRDSMRLHLASI----TPPDIENWEPLIVIANTKS 214
            |:..|:.:...    .|||        |.|.|....|.|..:    .|||.   .||:|..|.||
Human   548 CFAEAERLYML----LKDM--------AVRGRLLTALVLPDLLHAKLPPDS---CPLLVFVNPKS 597

  Fly   215 GSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPC-RILVAGGDGTIGWVLNTIYT 278
            |...|.::|...|..|:|.||.:|.:.||...|...::.   || |:||.|||||:||||..:..
Human   598 GGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQV---PCFRVLVCGGDGTVGWVLGALEE 659

  Fly   279 LNIK---PQPSVAIMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLH 340
            ...:   |:|||||:||||||||.|||.||| ..|..||..:|.|:..|.:|.:||:.:.:: .|
Human   660 TRYRLACPEPSVAILPLGTGNDLGRVLRWGA-GYSGEDPFSVLLSVDEADAVLMDRWTILLD-AH 722

  Fly   341 YRLPIQR-----HPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQV 400
            .....:.     .|.|.:.:.||..:|:||.::.:||:.||......:||:.||.:|...|.|::
Human   723 EAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKI 787

  Fly   401 MQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCKLCELSNANGEVRIVN-SISDGMM 464
            ......|  :::.|.::.:.|:||.::.|:|:||.|||:|   .:|..::.:.|... .:.||::
Human   788 SHSRSLH--KQIRLQVERQEVELPSIEGLIFINIPSWGSG---ADLWGSDSDTRFEKPRMDDGLL 847

  Fly   465 EVFGIVSSFHIAQLQCNISKPVRIGQAKQIRLQVKETVPMQADGEPWMQSPADIRLSS 522
            ||.|:....|:.|:|..:...:||.|....|:.:.:..|:|.|||||:|:|..:.:|:
Human   848 EVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	2/10 (20%)
		LCB5	207..519	CDD:224513	114/321 (36%)
		DAGKc	207..331	CDD:214487	57/127 (45%)
		DAGK_acc	355..510	CDD:279003	47/155 (30%)
DGKQ	NP_001338.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		C1	61..108	CDD:237996
		C1	122..169	CDD:294036
		C1	186..234	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..295
		UBQ	296..>348	CDD:294102
		DAGK_delta_RA	395..492	CDD:176378
		LXXLL motif 1. /evidence=ECO:0000305\|PubMed:17664281	555..559		0/7 (0%)
		LXXLL motif 2. /evidence=ECO:0000305\|PubMed:17664281	574..578		1/3 (33%)
		DAGKc	590..714	CDD:214487	57/127 (45%)
		DAGKa	741..893	CDD:214486	47/156 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275907at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820