DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dgkepsilon and DGKB

DIOPT Version :9

Sequence 1:NP_001286362.1 Gene:Dgkepsilon / 36408 FlyBaseID:FBgn0020930 Length:534 Species:Drosophila melanogaster
Sequence 2:NP_001337634.1 Gene:DGKB / 1607 HGNCID:2850 Length:804 Species:Homo sapiens


Alignment Length:606 Identity:173/606 - (28%)
Similarity:263/606 - (43%) Gaps:116/606 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GTIELSVEALIGSLLALSILFAF-CRSLLSEDFVSTFKTRHSWKSIKVLEQACFCNVCEILL--T 65
            ||:.|. |.:.|.:..:.:|... ..:.:.:|      .:|.|: :|...:..:||:|..:|  .
Human   212 GTVSLE-EWIQGGMTTIPLLVLLGLENNVKDD------GQHVWR-LKHFNKPAYCNLCLNMLIGV 268

  Fly    66 PSAGLFCDCCGLCTH------ATPPCQRRADREYRCKDKWLRNESSVRHLWVHGNLPMGVHCADC 124
            ...||.|..|....|      |.|.|.:.     ..|.|  ||...:.|.||.||.|  ..|..|
Human   269 GKQGLCCSFCKYTVHERCVARAPPSCIKT-----YVKSK--RNTDVMHHYWVEGNCP--TKCDKC 324

  Fly   125 NEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEFKDMIFPPYSF--VAARTR-- 185
            ::.|..:    .||.|..|.|||...||.|.:..  ...||.|..||.|.||.:.  |..:|.  
Human   325 HKTVKCY----QGLTGLHCVWCQITLHNKCASHL--KPECDCGPLKDHILPPTTICPVVLQTLPT 383

  Fly   186 ---------------------------DSMRLHLAS----------ITPPDIENWEPLIVIANTK 213
                                       |..::..|:          :||  :....||:|..|.|
Human   384 SGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTP--VPGTHPLLVFVNPK 446

  Fly   214 SGSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYT 278
            ||...|..:....:..|:|.||..|...||...|.:.....  ..|:|..|||||:||||:.|..
Human   447 SGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVP--DFRVLACGGDGTVGWVLDCIEK 509

  Fly   279 LNIKPQPSVAIMPLGTGNDLSRVLGWGA--EPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLHY 341
            .|:...|.|||:||||||||:|.|.||.  |..:::   |||:.|..:..:.|||:..::     
Human   510 ANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLM---KILKDIENSTEIMLDRWKFEV----- 566

  Fly   342 RLPIQR----HPTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQ 402
             :|..:    .|.....:.||||:||||.|.:.||..||......:||:.||..||.|||.:...
Human   567 -IPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFS 630

  Fly   403 PGCEHIEEKLTLYLDNKPVQL--PELQALVFLNIDS-------WGAGCK-----LCELSNANGEV 453
            ..|:.:.|.:.:..|...:.|  ..|:.:..|||.|       ||...|     ..|...::...
Human   631 ATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRT 695

  Fly   454 RIVNS---------ISDGMMEVFGIVSSFHIAQLQCNI-SKPVRIGQAKQIRLQVKETVPMQADG 508
            .:.::         :||.::||.|:..:..:.|:...: |...|:.|...:.::..:::|||.||
Human   696 TVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDG 760

  Fly   509 EPWMQSPADIRLSSRSQARVL 529
            |||||:|..|:::.::||.:|
Human   761 EPWMQTPCTIKITHKNQAPML 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DgkepsilonNP_001286362.1 C1_1 108..165 CDD:278556 19/56 (34%)
LCB5 207..519 CDD:224513 108/341 (32%)
DAGKc 207..331 CDD:214487 49/125 (39%)
DAGK_acc 355..510 CDD:279003 49/178 (28%)
DGKBNP_001337634.1 DAG_kinase_N 6..149 CDD:373103
EFh 153..222 CDD:238008 4/10 (40%)
C1 245..294 CDD:237996 14/49 (29%)
C1_1 310..359 CDD:365894 19/56 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..406 0/20 (0%)
DAGKc 440..561 CDD:214487 49/125 (39%)
DAGKa 582..762 CDD:214486 49/179 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694 4/20 (20%)
Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522 771..804 3/11 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155657
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000241
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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