Protein Alignment Dgkepsilon and DGKA

DIOPT Version :9

• Sequence 1: NP_001286362.1
• Gene: Dgkepsilon / 36408
• FlyBaseID: FBgn0020930
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_016874389.1
• Gene: DGKA / 1606
• HGNCID: 2849
• Length: 891
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 168/541 - (31%)
• Similarity: 254/541 - (46%)
• Gaps: 78/541 - (14%)

  Fly    42 RHSWKSIKVLEQACFCNVCEILL-TPSAGLFCDCC-----GLCTHATPPCQRRADREYRCKDKWL 100
            :|.|:. |...:..:||:||..: ....||.|:.|     ..|.....||:.....:.| ||..:
Human   361 QHMWRP-KRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSR-KDIGV 423

  Fly   101 RNESSVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACD 165
            ::     |:||.|....| .|..|.:::..:.|    |.|..|.||....|:||.....  ..||
Human   424 QS-----HVWVRGGCESG-RCDRCQKKIRIYHS----LTGLHCVWCHLEIHDDCLQAVG--HECD 476

  Fly   166 LGEFKDMIFPPYSF---------------VAARTRDSMRLHLASITPPD-IENWEPLIVIANTKS 214
            .|..:|.|.||.|.               .:.:|.|.:.|..:.....| :.|..||:|..|.||
Human   477 CGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKS 541

  Fly   215 GSSTGANVLSLLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTL 279
            |...|..||...:..|:|.||..|...||:..|: ..|..| ..||||.|||||:||:|.||...
Human   542 GGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLR-LFKDVP-DSRILVCGGDGTVGWILETIDKA 604

  Fly   280 NIKPQPSVAIMPLGTGNDLSRVLGWGA--EPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLHYR 342
            |:...|.||::||||||||:|.|.||.  |..::   .|||:.:..::.|::||:.:::
Human   605 NLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNL---AKILKDLEMSKVVHMDRWSVEV------ 660

  Fly   343 LPIQRH----PTKTIHVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQP 403
            :|.|..    |.....:.||||:||||.|.:.||..||......:||:.|||.||.|.|.:.:..
Human   661 IPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFS 725

  Fly   404 GCEHIEEKLTLYLDNKPVQLP--ELQALVFLNIDSWGAGCKLC-ELSNANGEVRIVN-------- 457
            .|:.:||.||:.:..||:.|.  .|:.:..|||.|...|..|. :....:|::..:|
Human   726 TCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAK 790

  Fly   458 -------------SISDGMMEVFGIVSSFHIAQLQCNISKP-VRIGQAKQIRLQVKETVPMQADG 508
                         .:||..:||.|:..:..:.|:...:... .|:.:..:|.....:|:|||.||
Human   791 VITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDG 855

  Fly   509 EPWMQSPADIRLSSRSQARVL 529
            |||||:|..|:::.::|..:|
Human   856 EPWMQTPCTIKITHKNQMPML 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	16/56 (29%)
		LCB5	207..519	CDD:224513	117/342 (34%)
		DAGKc	207..331	CDD:214487	53/125 (42%)
		DAGK_acc	355..510	CDD:279003	53/179 (30%)
DGKA	XP_016874389.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810