Protein Alignment Dgkepsilon and dgkk

DIOPT Version :10

• Sequence 1: NP_725228.1
• Gene: Dgkepsilon / 36408
• FlyBaseID: FBgn0020930
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_004916836.1
• Gene: dgkk / 100496859
• XenbaseID: XB-GENE-22063413
• Length: 1154
• Species: Xenopus tropicalis
• Alignment Length: 802
• Identity: 186/802 - (23%)
• Similarity: 283/802 - (35%)
• Gaps: 306/802 - (38%)

  Fly     2 DIGTIELSVEALIGSLLALS-----ILFAFCRSLLSEDFVSTFKTRHSWKSIKVLE--------- 52
            |....|.|.:.:..|...::     ||.|..|..: ||::...|:...|:..:..:
 Frog   113 DASVAETSTKNINNSFTVITPFRKLILCAENRKEM-EDWIGALKSVQKWELNETTQFNMEHFSGM 176

  Fly    53 ---QAC------FCNVCEILLT--PSAGLFCDCCGLCTHATPPCQRRADREYRCKDKW------- 99
               .||      |||||...|:  .|.||.|:.|....|..  |..||..  .|  ||
 Frog   177 HNWYACSHARPTFCNVCREALSGVTSHGLSCEVCKFKAHKR--CAVRATN--NC--KWTTLASVG 235

  Fly   100 ---LRNES--SVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRAD 159
               :.:|.  |:.|.|:.||||:...|..|    |....:...|..|||.||:...|..|..:..
 Frog   236 NDIIEDEDGVSMPHQWLEGNLPVSAKCEVC----DKTCGSVRRLQDWRCLWCKAIVHTSCKEQLG 296

  Fly   160 SMEACDLGEFKDMIFPPYSFVAARTRDSMRLHLASITPPDIENWEPLIVIANTKSGSSTGANVLS 224
            .:  |.||..:..|.||   :|..:.||.....|: :|....:  ||:|..|:|||.:.|...|.
 Frog   297 KI--CPLGPCRVSIIPP---IALNSIDSDGFWKAT-SPASCAS--PLLVFVNSKSGDNQGVKFLR 353

  Fly   225 LLRGYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKPQPSVAI 289
            ..:.:|:|.||.:|.:.|||..|:...|.|  ..||||.||||::||||:.|..|.::.|..:.:
 Frog   354 KFKQFLNPAQVFDLMNGGPQLGLRLFQKFS--NFRILVCGGDGSVGWVLSEIDKLGLQKQCQLGV 416

  Fly   290 MPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDR----------------------- 331
            :||||||||:||||||:........::||..:.||.:..|||
 Frog   417 LPLGTGNDLARVLGWGSLCDDDAQLLQILEKLERATTKMLDRWSILTYESPKHSPPAIREEENGE 481

  Fly   332 --FDLQI---------------------------------------------------------- 336
              |.:||
 Frog   482 AKFQVQISQYADSVAFHLAKILESDKHCDVISSAKFLCLSVNDFITEVGKAYARAAENREEADNM 546

  Fly   337 --------EKLHYRL-------------PIQR-HP------------------------------ 349
                    |||...:             |:|. ||
 Frog   547 ARKCSMLNEKLESLVRSLNEESQALLAPPLQSLHPDSALKENSKDVNEKENNMEDMAKIFKSKEQ 611

  Fly   350 --------------------------TKTIHVY-------------------------------- 356
                                      .|...||
 Frog   612 LMLRANSLKKALKQIIEQAEKAVDEQNKHTQVYSTPMLSPIQKESSEEFSKEGESLASRRGTISS 676

  Fly   357 --------------------------------NYFSVGVDAYITYNFHKTRESRFYLLSSRIFNK 389
                                            |||.:|:||.|:..|:..|:......|||..|.
 Frog   677 TTSSIILDRPYTFSPLHFSEDAIQFSERCTMNNYFGIGLDAKISLEFNNKRDEHPKKCSSRTRNM 741

  Fly   390 LLYFTFGTQQVMQPGCEHIEEKLTLYLDNKPVQLPELQALVFLNIDSWGAGCKLCELSNANGEVR 454
            :.|...||::::|...:::|:::.|..|.:|:.||.||.:..|||.|:..|.      |..|..:
 Frog   742 MWYGVLGTKELLQKTYKNLEQRVKLECDGEPISLPSLQGIAVLNIPSYAGGI------NFWGGTK 800

  Fly   455 IVN-----SISDGMMEVFGIVSSFHIAQLQCNISKPV-----RIGQAKQIRLQV--KETVPMQAD 507
            ..|     |..|..:||..:..|..:|     :|:.:     ||.|.:.:::.:  :|.||:|.|
 Frog   801 EDNNFGAPSFDDKKLEVVAVFGSIQMA-----VSRVINLQHHRIAQCRVVKITILGEEGVPVQVD 860

  Fly   508 GEPWMQSPADIRLSSRSQARVL 529
            ||.|:|.|..:::..:::|::|
 Frog   861 GEAWVQPPGILKIQHKNRAQML 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_725228.1	C1_DGKepsilon_typeIII_rpt1	40..96	CDD:410351	19/75 (25%)
		C1_DGK_rpt2	108..167	CDD:410355	18/58 (31%)
		DAGKc	207..331	CDD:214487	52/123 (42%)
		DAGK_acc	356..510	CDD:459866	50/229 (22%)
dgkk	XP_004916836.1	PH_DGK_type2	68..164	CDD:270093	12/51 (24%)
		C1	148..233	CDD:412127	24/90 (27%)
		C1_DGKeta_rpt2	244..305	CDD:410444	21/66 (32%)
		DAGKc	336..458	CDD:214487	52/123 (42%)
		DAGKa	706..863	CDD:214486	49/167 (29%)
		SAM_superfamily	1087..1150	CDD:472832