DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgkepsilon and dgke

DIOPT Version :9

Sequence 1:	NP_001286362.1	Gene:	Dgkepsilon / 36408	FlyBaseID:	FBgn0020930	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_002937855.1	Gene:	dgke / 100489119	XenbaseID:	XB-GENE-990685	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	198/502 - (39%)
Similarity:	287/502 - (57%)	Gaps:	37/502 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RHSWKSIKVLEQACFCNVC--EILLTPSAGLFCDCCGLCTHATPPCQRRADREYRCKDKWLRNES 104
            :|.|:...:..:..:|:||  .||    .|::|..||||  |...|.|||:|.:.||:..|..|.
Frog    44 KHGWQDTDLFGKPTYCSVCGQHIL----HGVYCRSCGLC--ADEACVRRANRRFPCKEIILWAEG 102

  Fly   105 SVRHLWVHGNLPMGVHCADCNEEVDHHVSTDPGLYGWRCAWCQRCYHNDCYTRADSMEACDLGEF 169
            ...| ||.||:|:...|:.|.::    ....|.|..:||.||||..|:||......:|.||.|||
Frog   103 RGHH-WVRGNVPLCSLCSVCGQQ----CGCQPKLCDYRCIWCQRTVHDDCMQNNLKIEDCDFGEF 162

  Fly   170 KDMIFPPYSFVAA-------RTRDSMRLHLASITPPDIENWEPLIVIANTKSGSSTGANVLSLLR 227
            |::|.|| |:::|       :|.|..:  |||...   :.|.||||:|||:||::.|..:||..:
Frog   163 KNLIIPP-SYLSAVTQLKKGKTTDYEK--LASSMG---KQWTPLIVLANTRSGNNMGEALLSEFK 221

  Fly   228 GYLHPLQVMELGSRGPQDALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKP----QPSVA 288
            |.|:|:||.:|....|..|||.......:..::||.|||||:||||:.:..:.||.    .|.||
Frog   222 GLLNPIQVFDLSKVSPFKALQLCTLLPDKSAKVLVCGGDGTVGWVLDAVDEMKIKGLEGCVPQVA 286

  Fly   289 IMPLGTGNDLSRVLGWGAEPPSVLDPVKILRSIRRARSVNLDRFDLQIEKLHYRLPIQRHPTKTI 353
            ::||||||||:..|||||.....:...:|||:|..|..:.|||:.:|:....|.|   |.| |.:
Frog   287 VLPLGTGNDLANTLGWGAGYAGDVPVEQILRNIMDADGIKLDRWKVQVTNKGYSL---RKP-KVL 347

  Fly   354 HVYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTLYLDN 418
            .:.||||||.||.:..|||..||....|.|||:.||.:|..:||:..:...|:.:.:|:.|.||.
Frog   348 SMNNYFSVGPDALMALNFHTHREKTPSLFSSRLVNKAVYLFYGTKDCLVQECKDLNKKVELELDG 412

  Fly   419 KPVQLPELQALVFLNIDSWGAGCKLCELSNANGEVRIVNSISDGMMEVFGIVSSFHIAQLQCNIS 483
            :.:.||.|:.:|.|||..||.||:|.|  ....|...::...||::||.|:..|||.||:|..::
Frog   413 ERIDLPNLEGIVVLNIGYWGGGCRLWE--GMGDEPYPLSRHDDGLLEVVGVYGSFHCAQIQVKLA 475

  Fly   484 KPVRIGQAKQIRLQVKET-VPMQADGEPWMQSPADIRLSSRSQARVL 529
            .|||:|||..:||.:|.: :|||.|||||.|.|..:.::.::.|.:|
Frog   476 NPVRLGQAHTVRLLLKSSKMPMQVDGEPWAQGPCTVTITHKTHALML 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	20/56 (36%)
		LCB5	207..519	CDD:224513	134/316 (42%)
		DAGKc	207..331	CDD:214487	55/127 (43%)
		DAGK_acc	355..510	CDD:279003	66/155 (43%)
dgke	XP_002937855.1	C1	45..88	CDD:381770	17/48 (35%)
		C1	105..148	CDD:237996	18/47 (38%)
		DAGKc	201..329	CDD:214487	55/127 (43%)
		DAGKa	349..503	CDD:214486	66/155 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2705
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275907at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		oto102455
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5376
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160