DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Taz and tafazzin

DIOPT Version :9

Sequence 1:	NP_477432.3	Gene:	Taz / 36405	FlyBaseID:	FBgn0026619	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001001814.1	Gene:	tafazzin / 321965	ZFINID:	ZDB-GENE-030131-684	Length:	262	Species:	Danio rerio

Alignment Length:	257	Identity:	116/257 - (45%)
Similarity:	164/257 - (63%)	Gaps:	2/257 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MPYNIDWIFPRLRNPSKFWYVVSQFVVSAVGIFSKVVLMFLNKPRVYNRERLIQLITKRPKGIPL 182
            ||..:.|.||:.  |...|.:.|:.|:..||.:|.:...:.|...|:|::.|:.|:.:||:..||
Zfish     1 MPLEVTWPFPQC--PRLGWRISSRVVMGMVGSYSYLWTKYFNSLMVHNQDVLLNLVDERPQDTPL 63

  Fly   183 VTVSNHYSCFDDPGLWGCLPLGIVCNTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPVVRGIGVY 247
            :||.||.||.|||.:||.|....:.|..|:||:.||.|||||.:.||.||..|||:|||||.|||
Zfish    64 ITVCNHQSCMDDPHIWGVLKFRQLWNLNKMRWTPAASDICFTREFHSSFFSRGKCVPVVRGDGVY 128

  Fly   248 QDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESPKIPIILPMWHEGMDDLLPN 312
            |..::..:|:...|.|||:||||:|||..|.:|:|||:||:|.|....||||||||.||:|:|||
Zfish   129 QKGMDFLLERLNQGEWIHIFPEGRVNMSGEFMRIKWGIGRLIAECSLHPIILPMWHIGMNDVLPN 193

  Fly   313 VEPYVIQRGKQVTLNVGQPLDLNDFILDLKKRQVPEPTARKLITDKIQEAFRDLRAETEKLH 374
            ..||:.:.|:::|:.||:|..:...:..|:.........||.:||.||:.||.|:|:.|.||
Zfish   194 ETPYIPRVGQRITVLVGKPFTVRHLVNALRAENTNPTEMRKTVTDYIQDEFRSLKAQAEALH 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taz	NP_477432.3	LPLAT_AGPAT-like	153..360	CDD:153251	95/206 (46%)
tafazzin	NP_001001814.1	LPLAT_AGPAT-like	34..241	CDD:153251	95/206 (46%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	69..74		3/4 (75%)
		Mitochondrial targeting sequence. /evidence=ECO:0000250\|UniProtKB:Q16635	82..92		2/9 (22%)
		Mitochondrial targeting sequence. /evidence=ECO:0000250\|UniProtKB:Q16635	155..190		20/34 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575140
Domainoid	1	1.000	163	1.000	Domainoid score	I3930
eggNOG	1	0.900	-	-		E1_KOG2847
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37264
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3252
OMA	1	1.010	-	-		QHG52876
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004731
OrthoInspector	1	1.000	-	-		oto39840
orthoMCL	1	0.900	-	-		OOG6_103216
Panther	1	1.100	-	-	LDO	PTHR12497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3957
SonicParanoid	1	1.000	-	-		X3327
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790