DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and RIPK2

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_003812.1	Gene:	RIPK2 / 8767	HGNCID:	10020	Length:	540	Species:	Homo sapiens

Alignment Length:	400	Identity:	89/400 - (22%)
Similarity:	147/400 - (36%)	Gaps:	125/400 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPVP----TRCQVLGRGAYGTVFKAIYRDRSVAVKIIRAQAASTLHNESHLLNLEHRNIVRLLKL 79
            |.:|    ...:.|.|||.|||..|.:.|..|.|      |...||..:.||:.|.::::|..::
Human    11 PTIPYHKLADLRYLSRGASGTVSSARHADWRVQV------AVKHLHIHTPLLDSERKDVLREAEI 69

  Fly    80 ESAADF----------------GLVIMECPRGQSLQRIV------DTLALPLMHRVLITLDVVAA 122
            ...|.|                |:|....|.| ||..::      ..:|.||..|:|  .::...
Human    70 LHKARFSYILPILGICNEPEFLGIVTEYMPNG-SLNELLHRKTEYPDVAWPLRFRIL--HEIALG 131

  Fly   123 LRYCHSQN--VLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQE 185
            :.|.|:..  :||.|:|..|||                 :...:..|:.|||.|       .|:.
Human   132 VNYLHNMTPPLLHHDLKTQNIL-----------------LDNEFHVKIADFGLS-------KWRM 172

  Fly   186 PSVAK----------GTLRYMSPEALRSDTLTEAS---DIYSLGITMWQLQARRLPYHTLDCNET 237
            .|:::          ||:.||.||.......:.||   ||||..:..|::.:|:.|:..:.....
Human   173 MSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQ 237

  Fly   238 IAYQ-------VVKHELRP-DNYHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRN---- 290
            |.|.       |:..|..| |..|:.::::|   |:..|             ..|...|.:
Human   238 IMYSVSQGHRPVINEESLPYDIPHRARMISL---IESGW-------------AQNPDERPSFLKC 286

  Fly   291 -LSLDPSYTVGRD---------LKKKR-----------HRNRLALHFDSPAPEGSACSESAYSQL 334
             :.|:|......:         |||.:           .:.::.|..:.|...|........|||
Human   287 LIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQL 351

  Fly   335 YKSCWVSAPE 344
            :::.  .:||
Human   352 HENS--GSPE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	78/332 (23%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	69/275 (25%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	76/331 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369		5/23 (22%)
		CARD_RIP2_CARD3	438..524	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900