DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mos and RIPK1

DIOPT Version :9

Sequence 1:NP_610817.1 Gene:Mos / 36404 FlyBaseID:FBgn0033773 Length:364 Species:Drosophila melanogaster
Sequence 2:NP_001341859.1 Gene:RIPK1 / 8737 HGNCID:10019 Length:671 Species:Homo sapiens


Alignment Length:383 Identity:94/383 - (24%)
Similarity:143/383 - (37%) Gaps:99/383 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DLLLNTPKRK--QLLKDGPPVPTRCQVLGRGAYGTVFKAIYRDRSVAV-KIIRAQAASTLHN--- 61
            |:.||..|.|  ..|:...        |..|.:|.|....:|.:.:.: |.:........||   
Human     4 DMSLNVIKMKSSDFLESAE--------LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL 60

  Fly    62 --ESHLLN-LEHRNIVRLL-KLESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAA 122
              |:.::| |.|..:|:|| .:.....:.||:....:|..:..:...::.||..:..|.|:::..
Human    61 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 125

  Fly   123 LRYCHSQNVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQE-- 185
            :.|.|.:.|:|.|:||.|||                 |...:..|:.|.|    :..|..|.:  
Human   126 MCYLHGKGVIHKDLKPENIL-----------------VDNDFHIKIADLG----LASFKMWSKLN 169

  Fly   186 ----------PSVAK---GTLRYMSPEALRSDTL--TEASDIYSLGITMWQLQARRLPYHTLDCN 235
                      ...||   |||.||:||.|.....  ||.||:||..:.:|.:.|.:.||....|.
Human   170 NEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICE 234

  Fly   236 ETIAYQVVKHELRPD-----NYHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRNL---- 291
            :.: ...:|...|||     .|...:|::|..                :|..||..||...    
Human   235 QQL-IMCIKSGNRPDVDDITEYCPREIISLMK----------------LCWEANPEARPTFPGIE 282

  Fly   292 -SLDPSY------TVGRDLK--KKRHRNRLA-------LHFDSPAPEGSACSESAYSQ 333
             ...|.|      :|..|:|  ||.:.|..|       |..|..|...|. |.||..|
Human   283 EKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSR-SNSATEQ 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MosNP_610817.1 STKc_Mos 19..298 CDD:270881 73/319 (23%)
S_TKc 26..257 CDD:214567 64/260 (25%)
RIPK1NP_001341859.1 STKc_RIP1 23..290 CDD:270929 72/304 (24%)
Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:10356400 290..582 15/51 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..354 5/10 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..458
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:11734559, ECO:0000269|PubMed:29681455 531..547
Death_RIP1 583..668 CDD:260048
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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