DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and MAP3K21

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_115811.2	Gene:	MAP3K21 / 84451	HGNCID:	29798	Length:	1036	Species:	Homo sapiens

Alignment Length:	362	Identity:	80/362 - (22%)
Similarity:	134/362 - (37%)	Gaps:	116/362 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QVLGRGAYGTVFKAIYRDRSVAVKIIR-------AQAASTLHNESHLL-NLEHRNIVRLLKLESA 82
            :::|.|.:|.|::|.::.:.||||..|       |.||.::..|:.|. .|.|.||:.|..:...
Human   128 ELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQ 192

  Fly    83 ADFGLVIMECPRGQSLQR-IVDTLALP------------LMHRVLI--TLDVVAALRYCHSQ--- 129
            .....:::|..||.:|.| :....|.|            :...||:  .:.:...:.|.|.:
Human   193 QPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257

  Fly   130 NVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPS--VAKGT 192
            .:||.|:|.:|||:....:....||.:         .|:.|||.:.|      |...:  ...||
Human   258 PILHRDLKSSNILLLEKIEHDDICNKT---------LKITDFGLARE------WHRTTKMSTAGT 307

  Fly   193 LRYMSPEALRSDTLTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDNYHQLKI 257
            ..:|:||.::|...::.|||:|.|:.:|:|....:||..:| ...:||.|..
Human   308 YAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGID-GLAVAYGVAV------------- 358

  Fly   258 LALDSPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRLALHFDSPAPE 322
                                                                |:|.|...|..||
Human   359 ----------------------------------------------------NKLTLPIPSTCPE 371

  Fly   323 GSACSESAYSQLYKSCWVSAPELRLSSIQLKHELEFI 359
                   .:::|.|.||...|.:|.|...:..:|..|
Human   372 -------PFAKLMKECWQQDPHIRPSFALILEQLTAI 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	65/299 (22%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	65/258 (25%)
MAP3K21	NP_115811.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		SH3_MLK4	42..97	CDD:212991
		PKc_like	129..401	CDD:328722	79/359 (22%)
		Leucine-zipper 1	425..446
		Leucine-zipper 2	460..481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	923..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900