DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Mlkl

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001297542.1	Gene:	Mlkl / 74568	MGIID:	1921818	Length:	472	Species:	Mus musculus

Alignment Length:	338	Identity:	75/338 - (22%)
Similarity:	130/338 - (38%)	Gaps:	95/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KQLLKD--GPPVPTRCQVLGRGAYGTVFKAIYRDRSVAVKII-RAQAAS------TLHNE-SHLL 66
            |::.|:  |||    ...|......|:::..|....|.:|:. ..||.|      |.::| ..:.
Mouse   184 KEIPKEHLGPP----WTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMK 244

  Fly    67 NLEHRNIVRLL-----KLESAADFGLVIMECPRGQSLQRIVD-TLALPLMHRVLITLDVVAALRY 125
            ..:..||:|:.     :.....:|.:|:..|..| :|:.::| ...|.:..|.|:.|.....|..
Mouse   245 KFDSPNILRIFGICIDQTVKPPEFSIVMEYCELG-TLRELLDREKDLTMSVRSLLVLRAARGLYR 308

  Fly   126 CHSQNVLHLDVKPTNILVALG------------TKSSITCNSSKIKVKRSYICKLCDFGSSIEMG 178
            .|....||.::..::.|||.|            |::||:..:...|.:||        .|:|
Mouse   309 LHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS--------SSTI--- 362

  Fly   179 EFCAWQEPSVAKGTLRYMSPEALRS-----DTLTEASDIYSLGITMWQLQARRLPYHTLDCNETI 238
                            |:|||.|::     |...|   |||.||.:|::...::|:.  .|:...
Mouse   363 ----------------YVSPERLKNPFCLYDIKAE---IYSFGIVLWEIATGKIPFE--GCDSKK 406

  Fly   239 AYQVVKHELRPDNYHQLKILALDSPIDCDWDLAHESTANVI--CRRANTSARRNLSLDPSYTVGR 301
            ..::|..:.:.:...|          ||.     |....:|  ||....|.|.::.       ||
Mouse   407 IRELVAEDKKQEPVGQ----------DCP-----ELLREIINECRAHEPSQRPSVD-------GR 449

  Fly   302 DLK-KKRHRNRLA 313
            .|. ::|...||:
Mouse   450 SLSGRERILERLS 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	66/311 (21%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	56/261 (21%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250\|UniProtKB:Q8NB16	1..143
Mlkl	NP_001297542.1	PHA02988	198..446	CDD:165291	64/295 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900