DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mos and MAP3K7

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_663304.1	Gene:	MAP3K7 / 6885	HGNCID:	6859	Length:	606	Species:	Homo sapiens

Alignment Length:	221	Identity:	63/221 - (28%)
Similarity:	104/221 - (47%)	Gaps:	48/221 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QVLGRGAYGTVFKAIYRDRSVAVKIIRAQA--ASTLHNESHLLNLEHRNIVRLLKLESAADFG-- 86
            :|:||||:|.|.||.:|.:.||:|.|.:::  .:.:.....|..:.|.|||:|        :|
Human    40 EVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKL--------YGAC 96

  Fly    87 ----LVIMECPRGQSLQRIVDTLALPL-----MHRVLITLDVVAALRYCHSQN---VLHLDVKPT 139
                .::||...|.||..::.. |.||     .|.:...|.....:.|.||..   ::|.|:||.
Human    97 LNPVCLVMEYAEGGSLYNVLHG-AEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPP 160

  Fly   140 N-ILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPSVAKGTLRYMSPEALRS 203
            | :|||.||                 :.|:||||::.::     ....:..||:..:|:||....
Human   161 NLLLVAGGT-----------------VLKICDFGTACDI-----QTHMTNNKGSAAWMAPEVFEG 203

  Fly   204 DTLTEASDIYSLGITMWQLQARRLPY 229
            ...:|..|::|.||.:|::..||.|:
Human   204 SNYSEKCDVFSWGIILWEVITRRKPF 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	63/221 (29%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	63/221 (29%)
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		63/221 (29%)
		STKc_TAK1	42..292	CDD:270960	62/219 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810