DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mos and Lrrk2

DIOPT Version :9

Sequence 1:NP_610817.1 Gene:Mos / 36404 FlyBaseID:FBgn0033773 Length:364 Species:Drosophila melanogaster
Sequence 2:NP_080006.3 Gene:Lrrk2 / 66725 MGIID:1913975 Length:2527 Species:Mus musculus


Alignment Length:334 Identity:79/334 - (23%)
Similarity:135/334 - (40%) Gaps:95/334 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GDLLLNTPKRKQL----------------------------LKDGPPVPTRCQVLGRGAYGTVFK 38
            ||||:| |.:.:|                            .::.|..     :||.|::|:|::
Mouse  1837 GDLLIN-PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEF-----LLGDGSFGSVYR 1895

  Fly    39 AIYRDRSVAVKIIRAQAASTLHNES--HLLNLEHRNIVRLLKLESAADF--GLVIMECPRGQSLQ 99
            |.|....|||||.....:..|..:.  .|.:|.|.:::.||    ||..  .:::||.....||.
Mouse  1896 AAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLL----AAGIRPRMLVMELASKGSLD 1956

  Fly   100 RIVD----TLALPLMHRVLITLDVVAALRYCHSQNVLHLDVKPTNILV-ALGTKSSITCNSSKIK 159
            |::.    :|...|.||  |.|.|...|||.||..:::.|:||.|:|: .|...::|        
Mouse  1957 RLLQQDKASLTRTLQHR--IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAI-------- 2011

  Fly   160 VKRSYICKLCDFGSSIEMGEFCAWQEPSVAKGTLRYMSPEALRSDTL-TEASDIYSLGITM---W 220
                 |.|:.|:|    :.::|.......::||..:.:||..|.:.: .:.:|:||.|:.:   |
Mouse  2012 -----IAKIADYG----IAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIW 2067

  Fly   221 QLQARRLPYHTLDCNETIAYQVVKHELR-PDNYHQLKILA-LDSPID----CDWDLAHESTANVI 279
            ...:|                 :...|| |:.:.:|.|.. |..|:.    ..|.:..:....  
Mouse  2068 TTGSR-----------------IMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITK-- 2113

  Fly   280 CRRANTSAR 288
            |.:.|...|
Mouse  2114 CLKENPQER 2122

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MosNP_610817.1 STKc_Mos 19..298 CDD:270881 72/289 (25%)
S_TKc 26..257 CDD:214567 64/244 (26%)
Lrrk2NP_080006.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..979
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1059 CDD:275380
LRR 4 1059..1080
leucine-rich repeat 1060..1084 CDD:275380
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1151
leucine-rich repeat 1131..1170 CDD:275380
leucine-rich repeat 1171..1197 CDD:275380
LRR 8 1174..1195
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1242
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
LRR 12 1269..1291
leucine-rich repeat 1270..1291 CDD:275380
Gem1 1333..1551 CDD:224025
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:292713
STKc_LRRK2 1884..2135 CDD:270970 71/281 (25%)
S_TKc 1884..2128 CDD:214567 71/281 (25%)
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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