DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Ripk3

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_064339.2	Gene:	Ripk3 / 56532	MGIID:	2154952	Length:	486	Species:	Mus musculus

Alignment Length:	408	Identity:	104/408 - (25%)
Similarity:	163/408 - (39%)	Gaps:	109/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RCQVLGRGAYGTVFKAIYR--DRSVAVKIIRAQAASTLHNESHLLNLEHRNIVRLLK-------- 78
            :.:.:|:|.:|.||:|.:|  :..|||||:.::..|  .....::||.:.|::.||.
Mouse    24 KLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS--WEVKAMVNLRNENVLLLLGVTEDLQWD 86

  Fly    79 -----------LESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAALRYCHSQN-- 130
                       :|:.:..||:..||||           ..||:.|:|  .:||..:.|.||.|
Mouse    87 FVSGQALVTRFMENGSLAGLLQPECPR-----------PWPLLCRLL--QEVVLGMCYLHSLNPP 138

  Fly   131 VLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFG-SSIEMGEFCAWQEPSVAK---G 191
            :||.|:||:|||                 :......||.||| |:.:.|........|.::   |
Mouse   139 LLHRDLKPSNIL-----------------LDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGG 186

  Fly   192 TLRYMSPEALRSDTL--TEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRP----- 249
            ||.|:.||.|....|  ::|||:||.||.:|.:.|.| ....:|....|...|...:.||
Mouse   187 TLAYLDPELLFDVNLKASKASDVYSFGILVWAVLAGR-EAELVDKTSLIRETVCDRQSRPPLTEL 250

  Fly   250 -------DNYHQLKILAL----------DSPIDCD------WDLAHESTANVICR-----RANTS 286
                   ....:||.|.:          .|..||:      ::|..:.....:..     ..:.|
Mouse   251 PPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRS 315

  Fly   287 ARRNLSL-DPSYT-VGRDLKKKRHRNRL--ALHFDSPA-PEGSACSESAYSQLYKSCWVSAPELR 346
            :.||||. :||.. ...|..::...:::  .||.:.|: |....|.|   .|...:....|...|
Mouse   316 SGRNLSAREPSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPE---RQAQDTSVGPATPAR 377

  Fly   347 LSS------IQLKHELEF 358
            .||      .|:.|.|.|
Mouse   378 TSSDPVAGTPQIPHTLPF 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	88/336 (26%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	75/271 (28%)
Ripk3	NP_064339.2	Pkinase	24..284	CDD:278497	78/292 (27%)
		PKc_like	28..284	CDD:304357	78/288 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..333		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..388		9/41 (22%)
		RHIM	410..457	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983	440..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5963
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.850