DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and MAP3K20

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens

Alignment Length:	352	Identity:	85/352 - (24%)
Similarity:	150/352 - (42%)	Gaps:	93/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GRGAYGTVFKA--IYRDRSVAVKIIRAQAASTLHNESHLLN-LEHRNIVRLLKLESAADFGLVIM 90
            |.|::|:|::|  |.:|:.||||.:     ..:..|:.:|: |.||||::.        :| ||:
Human    23 GGGSFGSVYRAKWISQDKEVAVKKL-----LKIEKEAEILSVLSHRNIIQF--------YG-VIL 73

  Fly    91 ECP------RGQSLQRIVDTL------ALPLMHRVLITLDVVAALRYCHSQ---NVLHLDVKPTN 140
            |.|      ...||..:.|.:      .:.:.|.:....||...:.|.|.:   .|:|.|:|..|
Human    74 EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRN 138

  Fly   141 ILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPSVAKGTLRYMSPEALRSDT 205
            :::|                 ...:.|:||||:|    .|..........||..:|:||.::|..
Human   139 VVIA-----------------ADGVLKICDFGAS----RFHNHTTHMSLVGTFPWMAPEVIQSLP 182

  Fly   206 LTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDNYHQLKILALDSPIDCD--- 267
            ::|..|.||.|:.:|::..|.:|:..|: ...:|:.||:...|           |..|..|.
Human   183 VSETCDTYSYGVVLWEMLTREVPFKGLE-GLQVAWLVVEKNER-----------LTIPSSCPRSF 235

  Fly   268 WDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRL-ALHFDSPAPEGSACSESAY 331
            .:|.|:      |..|:...|      ||:        |:..:.| ::..|:..|:  .|:...:
Human   236 AELLHQ------CWEADAKKR------PSF--------KQIISILESMSNDTSLPD--KCNSFLH 278

  Fly   332 SQLYKSCWVSAPELRLSSIQLKHELEF 358
            ::....|.:.|...||.  :|:.:|.|
Human   279 NKAEWRCEIEATLERLK--KLERDLSF 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	73/289 (25%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	63/245 (26%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	75/306 (25%)
		STYKc	23..260	CDD:214568	74/303 (24%)
		Leucine-zipper	287..308		6/19 (32%)
		SAM_MLTK	338..408	CDD:188928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900