DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mos and TNNI3K

DIOPT Version :9

Sequence 1:NP_610817.1 Gene:Mos / 36404 FlyBaseID:FBgn0033773 Length:364 Species:Drosophila melanogaster
Sequence 2:NP_057062.1 Gene:TNNI3K / 51086 HGNCID:19661 Length:835 Species:Homo sapiens


Alignment Length:389 Identity:91/389 - (23%)
Similarity:153/389 - (39%) Gaps:88/389 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LLKDGPPVPTRCQ--------VLGRGAYGTVFKAIYRDRSVAVKIIRAQAAST-------LHNES 63
            ||:.|.|.....|        ::|.|::|.|:|...|::.||:|..||....:       ....|
Human   447 LLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVS 511

  Fly    64 HLLNLEHRNIVRLLK--LESAADFGLVIMECPRGQ--SL----QRIVDTLALPLMHRVLITLDVV 120
            .|..|.|..:::.:.  |...:.|.:|......|.  ||    :||:|     |..:::|.:||.
Human   512 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD-----LQSKLIIAVDVA 571

  Fly   121 AALRYCH--SQNVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAW 183
            ..:.|.|  :|.::|.|:...|||:.....:.:                 .|||.|..:...   
Human   572 KGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVV-----------------ADFGESRFLQSL--- 616

  Fly   184 QEPSVAK--GTLRYMSPEALRSDT-LTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKH 245
            .|.::.|  |.||:|:||.....| .|..:|::|..:.:|::....:|:..|. ....|..:..|
Human   617 DEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLK-PAAAAADMAYH 680

  Fly   246 ELRPD-NYHQLKILALDSPIDC----DWDLAHE----------STANVICR---RANTSARRNLS 292
            .:||. .|      ::..||..    .|:...|          .....:|.   .:..|:..:.|
Human   681 HIRPPIGY------SIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGS 739

  Fly   293 LDPSYT----VGRDLKKKRH----RNRLALHFDSPAPEGSACSESAYSQLYKSCWVSAPELRLS 348
            |.||.:    |.|....:.|    |:|..|.:...|...:|.|:||..  |.|..:|..|::.|
Human   740 LSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQ--YSSQGLSLEEMKRS 801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MosNP_610817.1 STKc_Mos 19..298 CDD:270881 72/324 (22%)
S_TKc 26..257 CDD:214567 61/259 (24%)
TNNI3KNP_057062.1 ANK <56..121 CDD:238125
ANK repeat 66..98 CDD:293786
ANK 1 66..96
ANK 99..220 CDD:238125
ANK repeat 100..131 CDD:293786
ANK 2 100..129
ANK 3 133..162
ANK repeat 134..164 CDD:293786
ANK 161..290 CDD:238125
ANK repeat 166..197 CDD:293786
ANK 4 166..195
ANK repeat 199..232 CDD:293786
ANK 5 199..228
ANK 229..360 CDD:238125
ANK 6 234..263
ANK repeat 234..262 CDD:293786
ANK repeat 269..302 CDD:293786
ANK 7 269..298
ANK repeat 304..337 CDD:293786
ANK 8 304..335
ANK 334..>401 CDD:238125
ANK repeat 339..369 CDD:293786
ANK 9 339..368
ANK 10 381..410
PKc_TNNI3K 469..722 CDD:270966 64/284 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..751 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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