DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and MAP3K11

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens

Alignment Length:	364	Identity:	80/364 - (21%)
Similarity:	130/364 - (35%)	Gaps:	110/364 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KDGPPVPTRC---------QVLGRGAYGTVFKAIYRDRSVAVKIIR-------AQAASTLHNESH 64
            :.|.|.|...         :|:|.|.:|.|::..:|...||||..|       :..|.::..|:.
Human   102 RGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEAR 166

  Fly    65 LL-NLEHRNIVRLLKLESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAALRYCHS 128
            |. .|.|.||:.|..:........::||...|..|.|.:....:|....|...:.:...:.|.|.
Human   167 LFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHC 231

  Fly   129 Q---NVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPS--V 188
            :   .|:|.|:|..|||:.    ..|..:..:.|.     .|:.|||.:.|      |.:.:  .
Human   232 EALVPVIHRDLKSNNILLL----QPIESDDMEHKT-----LKITDFGLARE------WHKTTQMS 281

  Fly   189 AKGTLRYMSPEALRSDTLTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDNYH 253
            |.||..:|:||.:::.|.::.||::|.|:.:|:|....:||..:|| ..:||.|..
Human   282 AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDC-LAVAYGVAV--------- 336

  Fly   254 QLKILALDSPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRLALHFDS 318
                                                                    |:|.|...|
Human   337 --------------------------------------------------------NKLTLPIPS 345

  Fly   319 PAPEGSACSESAYSQLYKSCWVSAPELRLSSIQLKHELE 357
            ..||       .::||...||...|..|.....:..:||
Human   346 TCPE-------PFAQLMADCWAQDPHRRPDFASILQQLE 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	65/300 (22%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	63/243 (26%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992	80/364 (22%)
		STKc_MLK3	113..379	CDD:271049	77/353 (22%)
		STYKc	117..376	CDD:214568	75/346 (22%)
		Leucine-zipper 1	403..424
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810