DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mos and Lrrk1

DIOPT Version :9

Sequence 1:NP_610817.1 Gene:Mos / 36404 FlyBaseID:FBgn0033773 Length:364 Species:Drosophila melanogaster
Sequence 2:NP_001178553.1 Gene:Lrrk1 / 308703 RGDID:1308000 Length:2013 Species:Rattus norvegicus


Alignment Length:325 Identity:81/325 - (24%)
Similarity:134/325 - (41%) Gaps:100/325 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 VLGRGAYGTV-FKAIYRDRSVAVK--------------------IIRAQAA----STLHNESHLL 66
            :||:|..||| ::|.|:.:.||||                    .:||..|    |....|:.:|
  Rat  1247 ILGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASML 1311

  Fly    67 N-LEHRNIVRLLKLESAADFGLVIMECPRGQSLQRIV-----DTLALPLMHRVL--ITLDVVAAL 123
            : |:|..||.|:.: |.......:...|.| ||..::     |:..:||.|.:.  |...:.:.|
  Rat  1312 HALQHPCIVSLIGI-SIHPLCFALELAPLG-SLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGL 1374

  Fly   124 RYCHSQNVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPSV 188
            .|.|.:|::..|:|..||||            ..:.||.....||.|:|.|.:     ::.|.::
  Rat  1375 AYLHKKNIIFCDLKSDNILV------------WSLSVKELINIKLSDYGISRQ-----SFHEGAL 1422

  Fly   189 -AKGTLRYMSPEALRSDTLTEASDIYSLGITMWQL---QARRLPYHTLDCNETIAYQVVK---HE 246
             .:||..|.:||........|..|::|.|:.:::|   |...|.:|.|        |:||   ..
  Rat  1423 GVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQL--------QIVKKLSKG 1479

  Fly   247 LRP-------DNYHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRNLSL-------DPSY 297
            :||       ..:::|:.|.:    :| ||...|              :|.|:|       ||::
  Rat  1480 IRPVLGQPEEVQFYRLQALMM----EC-WDTKPE--------------KRPLALSVVSQMKDPTF 1525

  Fly   298  297
              Rat  1526  1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MosNP_610817.1 STKc_Mos 19..298 CDD:270881 81/325 (25%)
S_TKc 26..257 CDD:214567 71/276 (26%)
Lrrk1NP_001178553.1 ANK 91..214 CDD:238125
ANK repeat 91..119 CDD:293786
Ank_2 126..221 CDD:289560
ANK repeat 156..186 CDD:293786
ANK repeat 188..218 CDD:293786
LRR_RI <273..464 CDD:238064
LRR <279..513 CDD:227223
leucine-rich repeat 281..303 CDD:275380
leucine-rich repeat 304..330 CDD:275380
leucine-rich repeat 331..381 CDD:275380
leucine-rich repeat 382..405 CDD:275380
leucine-rich repeat 406..451 CDD:275380
leucine-rich repeat 452..474 CDD:275380
leucine-rich repeat 475..498 CDD:275380
leucine-rich repeat 499..549 CDD:275380
leucine-rich repeat 550..572 CDD:275380
Gem1 635..>781 CDD:224025
P-loop_NTPase 639..821 CDD:304359
COR 844..1036 CDD:292713
S_TKc 1247..1511 CDD:214567 76/309 (25%)
STKc_LRRK1 1248..1523 CDD:270969 79/320 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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