DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Map3k10

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001382027.1	Gene:	Map3k10 / 308463	RGDID:	1308381	Length:	940	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	80/368 - (21%)
Similarity:	135/368 - (36%)	Gaps:	115/368 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPVPTRCQ--------------VLGRGAYGTVFKAIYRDRSVAVKIIR-------AQAASTLHNE 62
            |..||..|              ::|.|.:|.|::|::|...||||..|       |..|..:..|
  Rat    81 PAAPTDLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQVRQE 145

  Fly    63 SHLLN-LEHRNIVRLLKLESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAALRYC 126
            :.|.. |:|.||:.|.....:.....::||..||.:|.|::....:|....|...:.|...:.|.
  Rat   146 ARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYL 210

  Fly   127 HSQ---NVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPS- 187
            |:.   .::|.|:|..|||:....::....::         :.|:.|||.:.|      |.:.:
  Rat   211 HNDAPVPIIHRDLKSINILILEAIENHNLADT---------VLKITDFGLARE------WHKTTK 260

  Fly   188 -VAKGTLRYMSPEALRSDTLTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDN 251
             .|.||..:|:||.:|....:::||::|.|:.:|:|....:||..:|. ..:||.|.
  Rat   261 MSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDA-LAVAYGVA-------- 316

  Fly   252 YHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRLALHF 316
                                                                     .|:|.|..
  Rat   317 ---------------------------------------------------------MNKLTLPI 324

  Fly   317 DSPAPEGSACSESAYSQLYKSCWVSAPELRLSSIQLKHELEFI 359
            .|..||       .:::|.:.||...|..|.....:..:||.|
  Rat   325 PSTCPE-------PFARLLEECWDPDPHGRPDFGSILKQLEVI 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	66/305 (22%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	63/257 (25%)
Map3k10	NP_001382027.1	Leucine-zipper 1	384..405
		Leucine-zipper 2	419..440
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810