DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Ripk4

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001100573.1	Gene:	Ripk4 / 304053	RGDID:	1311691	Length:	786	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	85/363 - (23%)
Similarity:	137/363 - (37%)	Gaps:	111/363 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LGRGAYGTVFKA--IYRDRSVAVKIIRAQAASTLHNESHLLNLEHRNIVRLL----KLESA---- 82
            :|...:|.|:|.  ::....:|:|.            |..|:::.|....||    |:|.|
  Rat    28 VGSDGFGQVYKVRHVHWKTWLAIKC------------SPSLHVDDRERTELLEEAKKMEMAKFRY 80

  Fly    83 --ADFGL------VIMECPRGQSLQRIVDTLALP------LMHRVLITLDVVAALRYCHSQNVLH 133
              ..:|:      ::||.....||::::.:..||      ::|...:.::.:    :|.|..:||
  Rat    81 ILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFL----HCMSPPLLH 141

  Fly   134 LDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFG----------SSIEM-GEFCAWQEPS 187
            ||:||.|||                 :...|..|:.|||          ..:.| |.|
  Rat   142 LDLKPANIL-----------------LDAHYHVKISDFGLAKCNGMSHSHDLSMDGLF------- 182

  Fly   188 VAKGTLRYMSPEALR--SDTLTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPD 250
               ||:.|:.||.:|  |.......|:||..|.:|.:..::.|:........|..:|||.. ||
  Rat   183 ---GTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFSDEKNILHIMMKVVKGH-RP- 242

  Fly   251 NYHQLKILALDSPIDCDWDLAHESTANVI-----CRRANTSARRNLSLDPSYTVGRDLKKKRHRN 310
               :|..:....|..|         |::|     |..|:...|.......|.|  .||.:|....
  Rat   243 ---ELPPICRPRPRAC---------ASLIGLMQRCWHADPQVRPTFQEITSET--EDLCEKPDEE 293

  Fly   311 RLALHFD-----SPAPEGSACSESAYSQLYKSCWVSAP 343
            ...|..:     ||.|...|..||  |:|.::   |||
  Rat   294 VKDLAHEPGEKSSPEPRSEARPES--SRLKRA---SAP 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	69/311 (22%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	61/265 (23%)
Ripk4	NP_001100573.1	STKc_RIP4_like	25..290	CDD:270927	72/320 (23%)
		TyrKc	26..279	CDD:197581	68/307 (22%)
		ANK repeat	442..470	CDD:293786
		Ank_2	444..536	CDD:289560
		ANK	471..591	CDD:238125
		ANK repeat	473..503	CDD:293786
		ANK repeat	505..536	CDD:293786
		ANK repeat	538..569	CDD:293786
		Ank_2	544..634	CDD:289560
		ANK repeat	571..602	CDD:293786
		ANK	600..725	CDD:238125
		ANK repeat	605..636	CDD:293786
		Ank_2	610..701	CDD:289560
		ANK repeat	638..669	CDD:293786
		ANK repeat	671..701	CDD:293786
		Ank_2	676..766	CDD:289560
		ANK	731..>766	CDD:238125
		ANK repeat	736..766	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900