DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Lrrk2

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001178718.1	Gene:	Lrrk2 / 300160	RGDID:	1561168	Length:	2526	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	77/333 - (23%)
Similarity:	135/333 - (40%)	Gaps:	93/333 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GDLLLNTPKRKQL----------------------------LKDGPPVPTRCQVLGRGAYGTVFK 38
            ||||:| |.:.:|                            .::.|..     :||.|::|:|::
  Rat  1836 GDLLIN-PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEF-----LLGDGSFGSVYR 1894

  Fly    39 AIYRDRSVAVKIIRAQAASTLHNES--HLLNLEHRNIVRLLKLESAADF--GLVIMECPRGQSLQ 99
            |.|....|||||.....:..|..:.  .|.:|.|.:::.||    ||..  .:::||.....||.
  Rat  1895 AAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLL----AAGIRPRMLVMELASKGSLD 1955

  Fly   100 RIVD----TLALPLMHRVLITLDVVAALRYCHSQNVLHLDVKPTNILV-ALGTKSSITCNSSKIK 159
            |::.    :|...|.||  |.|.|...|||.||..:::.|:||.|:|: .|...::|
  Rat  1956 RLLQQDKASLTRTLQHR--IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAI-------- 2010

  Fly   160 VKRSYICKLCDFGSSIEMGEFCAWQEPSVAKGTLRYMSPEALRSDTL-TEASDIYSLGITM---W 220
                 |.|:.|:|    :.::|.......::||..:.:||..|.:.: .:.:|:||.|:.:   |
  Rat  2011 -----IAKIADYG----IAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIW 2066

  Fly   221 QLQARRLPYHTLDCNETIAYQVVKHELRPDNYHQLKILA-LDSPID----CDWDLAHESTANVIC 280
                            |...::::....|:.:.:|.|.. |..|:.    ..|.:..:....  |
  Rat  2067 ----------------TTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITK--C 2113

  Fly   281 RRANTSAR 288
            .:.|...|
  Rat  2114 LKENPQER 2121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	70/288 (24%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	62/243 (26%)
Lrrk2	NP_001178718.1	leucine-rich repeat	984..1011	CDD:275380
		leucine-rich repeat	1012..1035	CDD:275380
		leucine-rich repeat	1036..1058	CDD:275380
		leucine-rich repeat	1059..1083	CDD:275380
		leucine-rich repeat	1084..1107	CDD:275380
		leucine-rich repeat	1108..1129	CDD:275380
		leucine-rich repeat	1130..1173	CDD:275380
		leucine-rich repeat	1174..1196	CDD:275380
		leucine-rich repeat	1197..1220	CDD:275380
		leucine-rich repeat	1221..1245	CDD:275380
		Gem1	1332..1550	CDD:224025
		RocCOR	1333..1506	CDD:206741
		COR	1526..1739	CDD:292713
		S_TKc	1883..2145	CDD:214567	69/280 (25%)
		STKc_LRRK2	1883..2134	CDD:270970	69/280 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900