DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mos and Tnni3k

DIOPT Version :9

Sequence 1:NP_610817.1 Gene:Mos / 36404 FlyBaseID:FBgn0033773 Length:364 Species:Drosophila melanogaster
Sequence 2:NP_861434.1 Gene:Tnni3k / 295531 RGDID:727908 Length:835 Species:Rattus norvegicus


Alignment Length:417 Identity:92/417 - (22%)
Similarity:159/417 - (38%) Gaps:106/417 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGDLLLNTPKRKQLLKDGPPVPTRC----------QVLGRGAYGTVFKAIYRDRSVAVKIIRAQA 55
            :|.:...|.::..:|.....:|:|.          :::|.|::|.|:|...|::.||:|..||..
  Rat   432 LGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANT 496

  Fly    56 AST-------LHNESHLLNLEHRNIVRLLK--LESAADFGLVIMECPRGQ--SL----QRIVDTL 105
            ..:       ....|.|..|.|..:|:.:.  |:..:.|.:|......|.  ||    :||:|  
  Rat   497 YCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILD-- 559

  Fly   106 ALPLMHRVLITLDVVAALRYCHS--QNVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKL 168
               |..:::|.:||...:.|.||  |.::|.|:...|||:.....:.:                 
  Rat   560 ---LQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVV----------------- 604

  Fly   169 CDFGSSIEMGEFCAWQEPSVAK--GTLRYMSPEALRSDT-LTEASDIYSLGITMWQLQARRLPYH 230
            .|||.|..:...   .|.::.|  |.||:|:||.....| .|..:|::|..:.:|:|....:|:.
  Rat   605 ADFGESRFLQSL---DEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYSLCLWELLTGEIPFA 666

  Fly   231 TLDCNETIAYQVVKHELRPD-NYHQLKILALDSPIDC----DWDLAHE----------STANVIC 280
            .|. ....|..:..|.:||. .|      ::..||..    .|:...|          .....:|
  Rat   667 HLK-PAAAAADMAYHHIRPPIGY------SIPKPISSLLIRGWNACPEGRPEFSEVVSKLEECLC 724

  Fly   281 R---RANTSARRNLSLDPSYT----VGRDLKKKRH----RNRLALHFDSPAPEGSACSESA---- 330
            .   .:..|:..:.||.||.:    :.|....:.|    |:|..|.:...|...:..|:|.    
  Rat   725 NVELMSPASSNSSGSLSPSSSSDCLLSRGGPGRSHVAALRSRFELEYALNARSYAGWSQSVGTHS 789

  Fly   331 --------------YSQLYKSCWVSAP 343
                          ||.:.|..:||.|
  Rat   790 NPGLSLEEMNRSTQYSTVDKYGYVSDP 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MosNP_610817.1 STKc_Mos 19..298 CDD:270881 75/326 (23%)
S_TKc 26..257 CDD:214567 63/251 (25%)
Tnni3kNP_861434.1 ANK repeat 66..98 CDD:293786
ANK 1 66..96
Ank_2 71..164 CDD:289560
ANK 99..220 CDD:238125
ANK repeat 100..131 CDD:293786
ANK 2 100..129
ANK 3 133..162
ANK repeat 134..164 CDD:293786
Ank_2 138..232 CDD:289560
ANK 161..290 CDD:238125
ANK repeat 166..197 CDD:293786
ANK 4 166..195
ANK repeat 199..232 CDD:293786
ANK 5 199..228
ANK 229..360 CDD:238125
ANK 6 234..263
ANK repeat 234..262 CDD:293786
Ank_4 238..287 CDD:290365
ANK repeat 269..302 CDD:293786
ANK 7 269..298
Ank_2 274..369 CDD:289560
ANK repeat 304..337 CDD:293786
ANK 8 304..335
ANK 334..>401 CDD:238125
ANK repeat 339..369 CDD:293786
ANK 9 339..368
Ank_4 340..401 CDD:290365
ANK 10 381..410
TyrKc 463..719 CDD:197581 67/287 (23%)
PKc_TNNI3K 469..722 CDD:270966 67/284 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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