DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Ripk3

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_647558.2	Gene:	Ripk3 / 246240	RGDID:	628899	Length:	478	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	85/347 - (24%)
Similarity:	129/347 - (37%)	Gaps:	123/347 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LGRGAYGTVFKAIYR--DRSVAVKIIRAQAASTLHNESHLLNLEHRNIVRLLK------------ 78
            :|:|.:|.||:|.:.  :..|||||:.::..|  .....::||.|.|::.||.
  Rat    28 VGKGGFGAVFRARHTAWNLDVAVKIVNSKKIS--REVKAMVNLRHENVLLLLGVTENLEWDYVYG 90

  Fly    79 -------LESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAALRYCHSQN--VLHL 134
                   :|:.:..||:...|||           ..||:.|:|  .:||..:.|.||.|  :||.
  Rat    91 PALVTGFMENGSLSGLLQPSCPR-----------PWPLLCRLL--EEVVLGMCYLHSLNPSLLHR 142

  Fly   135 DVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMG--EFCAWQEPSVAKGTLRYMS 197
            |:||:|:|                 :......||.|||.|...|  :..:......:.|||.|::
  Rat   143 DLKPSNVL-----------------LDPELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLA 190

  Fly   198 PEALRSD-TLTEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDNYHQLKILALD 261
            ||.|.:| ..::|||:||.|:.:|.:.|.| ....:|....|...|...:.||    .|..|..|
  Rat   191 PELLDNDGKASKASDVYSFGVLVWTVLAGR-EAEVVDKTSLIRGAVCNRQRRP----PLTELPPD 250

  Fly   262 SPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRLALHFDSPAPEGSAC 326
            ||                                                     ::|..||
  Rat   251 SP-----------------------------------------------------ETPGLEG--- 259

  Fly   327 SESAYSQLYKSCWVSAPELRLS 348
                ..:|...||.|.|:.|.|
  Rat   260 ----LKELMTHCWSSEPKDRPS 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	75/295 (25%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	71/254 (28%)
Ripk3	NP_647558.2	PKc_like	28..285	CDD:419665	85/347 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..429
		RHIM	408..458	CDD:403811
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250\|UniProtKB:Q9Y572	437..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900