DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and Ripk1

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001346926.1	Gene:	Ripk1 / 19766	MGIID:	108212	Length:	656	Species:	Mus musculus

Alignment Length:	362	Identity:	79/362 - (21%)
Similarity:	127/362 - (35%)	Gaps:	118/362 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LGRGAYGTVFKAIYRDRSVAV--KII----RAQAASTLHNESHLLN-LEHRNIVRLLK-LESAAD 84
            |..|.:|.|....:|.....:  |:.    ||:....|..|..::: |.|..:|:||. :....:
Mouse    23 LDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGN 87

  Fly    85 FGLVIMECPRGQSLQRIVDTLALPLMHRVLITLDVVAALRYCHSQNVLHLDVKPTNILVALGTKS 149
            :.||:....:|..:..:...:.:||..:..|.::.:..:.|.|.:.|:|.|:||.|||
Mouse    88 YSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENIL------- 145

  Fly   150 SITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPSVAK----------------GTLRYMSP 198
                      |.|.:..|:.|.|    :..|..|.:.:..|                |||.||:|
Mouse   146 ----------VDRDFHIKIADLG----VASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAP 196

  Fly   199 EALRSDTL--TEASDIYSLGITMWQLQARRLPYHTLDCNETIAYQVVKHELRPDNYHQLKILALD 261
            |.|.....  ||.||:||.||.:|.:.|::.||..:.|.|..
Mouse   197 EHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQF----------------------- 238

  Fly   262 SPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLKKKRHRNRLALHFDSPAPEGSAC 326
                            |||.::..  |.|:.....|                            |
Mouse   239 ----------------VICIKSGN--RPNVEEILEY----------------------------C 257

  Fly   327 SESAYSQLYKSCWVSAPELRLSSIQLKHELE-FILCH 362
            .....| |.:.||.:.||.|.:.:.::.|.. |.|.|
Mouse   258 PREIIS-LMERCWQAIPEDRPTFLGIEEEFRPFYLSH 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	66/295 (22%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	61/254 (24%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	77/358 (22%)
		Interaction with SQSTM1. /evidence=ECO:0000250\|UniProtKB:Q13546	291..567		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..373
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983, ECO:0000269\|PubMed:27819681, ECO:0000269\|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900