DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and MLKL

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_689862.1	Gene:	MLKL / 197259	HGNCID:	26617	Length:	471	Species:	Homo sapiens

Alignment Length:	326	Identity:	81/326 - (24%)
Similarity:	127/326 - (38%)	Gaps:	88/326 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RKQLLKDGPPVPTRCQVLGRGAYGTVFKAIYRDRSVAVKII-RAQAAS------TLHNE-SHLLN 67
            :|:.|...|.:     :|......|::|..|....||:|:. :.||.|      |.:.| ..:..
Human   197 KKEQLSGSPWI-----LLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKK 256

  Fly    68 LEHRNIVRLL-----KLESAADFGLVIMECPRGQSLQRIVD-TLALPLMHRVLITLDVVAALRYC 126
            .|..||:|:.     :..:...|.:|:..|..| :|:.::| ...|.|..|:::.|.....|...
Human   257 FESPNILRIFGICIDETVTPPQFSIVMEYCELG-TLRELLDREKDLTLGKRMVLVLGAARGLYRL 320

  Fly   127 HSQNV--LHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIEMGEFCAWQEPSVA 189
            |....  ||..::.:|.||..|                 |..||..|    |:.:    .:.|::
Human   321 HHSEAPELHGKIRSSNFLVTQG-----------------YQVKLAGF----ELRK----TQTSMS 360

  Fly   190 KGTLR----------YMSPEALRSDTLTE---ASDIYSLGITMWQLQARRLPYHTLDCN-ETIAY 240
            .||.|          |:||:.| .|...:   .|:|||.||.:|::....:|:.  .|| |.|..
Human   361 LGTTREKTDRVKSTAYLSPQEL-EDVFYQYDVKSEIYSFGIVLWEIATGDIPFQ--GCNSEKIRK 422

  Fly   241 QV-VKHELRPDNYHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRNLSLDPSYTVGRDLK 304
            .| ||.:..|        |..|.|.:.. ::..|      ||..:.|.|      ||  |...||
Human   423 LVAVKRQQEP--------LGEDCPSELR-EIIDE------CRAHDPSVR------PS--VDEILK 464

  Fly   305 K 305
            |
Human   465 K 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	75/309 (24%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	64/261 (25%)
MLKL	NP_689862.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000269\|PubMed:29883610	1..149
		PHA02988	177..469	CDD:165291	81/326 (25%)
		PKc_like	215..466	CDD:304357	77/303 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900