DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and lrk-1

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_492839.4	Gene:	lrk-1 / 172995	WormBaseID:	WBGene00003068	Length:	2393	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	92/421 - (21%)
Similarity:	159/421 - (37%)	Gaps:	140/421 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RCQVLGRGAYGTVFKAIYRDRS-----VAVKIIR------------------------------- 52
            |.::|||||:|.||:|..|..:     ||.|::.
Worm  1696 RSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFA 1760

  Fly    53 AQAASTLHNESHLLN-LEHRNIVRLLKLESAADFGLVIMECPRGQSLQRIVDTLALPLMHRVLIT 116
            .:|..|...|..||: ::|.|::.|:.: ......||:...|.| :|.:::.:      ||...|
Worm  1761 CRAYCTSRQELSLLSRMKHPNVIGLVGV-CTFPLSLVVELAPLG-ALNQLLGS------HRKAGT 1817

  Fly   117 -----------LDVVAALRYCHSQNVLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCD 170
                       :.|..||.|.||.::::.|:|..|:   ||.:.     .:....:...:.||.|
Worm  1818 KLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENV---LGWRF-----PAPFSPQTDVLLKLGD 1874

  Fly   171 FGSSIEMGEFCAWQEPS-VAK---GTLRYMSPEALR---SDTLTEASDIYSLGITMWQLQARRLP 228
            :|.|..:       .|| .||   ||..:|:||.:|   .:..|:..|.:|.|:.:::|...:.|
Worm  1875 YGISRSV-------LPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFP 1932

  Fly   229 YHT--------LDCNETIAYQVVKHELRPDNYHQLKILALDSPIDCDWDLAHESTANVICRRANT 285
            :.:        ||....:   ::.|||      .|....||..:.| |....||       |.::
Worm  1933 FESEEHVKERMLDGARPV---LLPHEL------LLPTPMLDLLVHC-WSAHPES-------RPSS 1980

  Fly   286 SARRNLSLDPSYT-------VGRDLKKKRHRNRLAL----HFDSPAPEGSACSESAYSQLYKSCW 339
            |........|.:|       :|..|...:   .:|:    ..|.|        :...:||    |
Worm  1981 SQLVGFCAAPEFTHLLDVCELGEALPPTQ---LMAVGITDEIDDP--------DDFEAQL----W 2030

  Fly   340 VSAPELRL-----------SSIQLKHELEFI 359
            :|..|:.:           .||:|.|..:::
Worm  2031 LSGREMVVMGCTQYGFVDQKSIELPHRGKYV 2061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	77/336 (23%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	67/293 (23%)
lrk-1	NP_492839.4	Ank_2	29..121	CDD:289560
		ANK	51..218	CDD:238125
		ANK repeat	56..88	CDD:293786
		ANK repeat	90..121	CDD:293786
		ANK	192..337	CDD:238125
		ANK repeat	197..228	CDD:293786
		Ank_2	202..286	CDD:289560
		ANK repeat	230..262	CDD:293786
		Ank_2	269..390	CDD:289560
		ANK	312..456	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:289560
		ANK repeat	398..432	CDD:293786
		LRR_RI	<512..>639	CDD:238064
		leucine-rich repeat	534..555	CDD:275380
		LRR_8	554..615	CDD:290566
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		LRR_8	718..776	CDD:290566
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR_8	857..915	CDD:290566
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop_NTPase	977..1160	CDD:304359
		COR	<1239..>1336	CDD:292713
		S_TKc	1698..1983	CDD:214567	75/324 (23%)
		PKc_like	1699..1990	CDD:304357	75/330 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900