DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mos and RIPK3

DIOPT Version :9

Sequence 1:	NP_610817.1	Gene:	Mos / 36404	FlyBaseID:	FBgn0033773	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens

Alignment Length:	376	Identity:	93/376 - (24%)
Similarity:	141/376 - (37%)	Gaps:	145/376 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QLLKDGPPVP-------TRCQVLGRGAYGTVFKAIYR--DRSVAVKIIRAQAAS-------TLHN 61
            :|...|.|.|       ...:::|:|.:||||:|.:|  ...|||||:.::|.|       :|.|
Human     5 KLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDN 69

  Fly    62 ESHLLNLEHRNIVRLLK-------------LESAADFGLVIMECPRGQSLQRIVDTLALPLMHRV 113
            | .:|.||  .::..:.             :|:.:..||:..:|||           ..||:.|:
Human    70 E-FVLRLE--GVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPR-----------PWPLLCRL 120

  Fly   114 LITLDVVAALRYCHSQN--VLHLDVKPTNILVALGTKSSITCNSSKIKVKRSYICKLCDFGSSIE 176
            |  .:||..:.|.|.||  :||.|:||:|:|:           ..::.|      ||.|||.|..
Human   121 L--KEVVLGMFYLHDQNPVLLHRDLKPSNVLL-----------DPELHV------KLADFGLSTF 166

  Fly   177 MGEFCAWQEPSVAKGTLRYMSPEAL-----RSDTLTEASDIYSLGITMWQLQARR---LPYHTLD 233
            .|...:........|||.|::||..     ::.|   |||:||.||.||.:.|.|   ||
Human   167 QGGSQSGTGSGEPGGTLGYLAPELFVNVNRKAST---ASDVYSFGILMWAVLAGREVELP----- 223

  Fly   234 CNETIAYQVVKHELRPDNYHQLKILALDSPIDCDWDLAHESTANVICRRANTSARRNL-SLDPSY 297
            ...::.|:.|                                    |.|.|..:...| ...|
Human   224 TEPSLVYEAV------------------------------------CNRQNRPSLAELPQAGP-- 250

  Fly   298 TVGRDLKKKRHRNRLALHFDSPAPEGSACSESAYSQLYKSCWVSAPELRLS 348
                               ::|..||       ..:|.:.||.|.|:.|.|
Human   251 -------------------ETPGLEG-------LKELMQLCWSSEPKDRPS 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mos	NP_610817.1	STKc_Mos	19..298	CDD:270881	81/318 (25%)
Mos	NP_610817.1	S_TKc	26..257	CDD:214567	74/262 (28%)
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	89/359 (25%)
		PKc_like	27..280	CDD:304357	89/354 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5963
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.850